Chen Shanquan, Fernandez-Egea Emilio, Jones Peter B, Lewis Jonathan R, Cardinal Rudolf N
Department of Psychiatry, University of Cambridge, UK.
Department of Psychiatry, University of Cambridge, UK; and Cambridgeshire and Peterborough NHS Foundation Trust, Fulbourn, UK.
BJPsych Open. 2021 Nov 2;7(6):e201. doi: 10.1192/bjo.2021.1046. eCollection 2021 Nov.
Persisting symptoms and dysfunction after SARS-CoV-2 infection have frequently been observed. However, information on the aftermath of COVID-19 is inadequate. We followed up people with severe mental illness (SMI) infected with SARS-CoV-2, and evaluated their longer-term mortality, using data from Cambridgeshire and Peterborough NHS Foundation Trust, UK. We examined the time course and duration of mortality risk from the point of diagnosis. After SARS-CoV-2 infection, people with SMI had a substantially higher risk of death (hazard ratio (HR) = 5.16, 95% confidence interval (CI) 1.56-17.03; = 0.007) during the first 28 days and during the following 28-60 days (HR = 2.96, 95% CI 1.21-7.26; = 0.018) than those without infection, but after 60 days the additional risk of death was no longer significant (HR = 2.33, 95% CI 0.83-6.53; = 0.107).
新型冠状病毒2（SARS-CoV-2）感染后持续出现症状和功能障碍的情况屡见不鲜。然而，关于新型冠状病毒肺炎（COVID-19）后遗症的信息并不充分。我们对感染了SARS-CoV-2的重症精神疾病（SMI）患者进行了随访，并利用英国剑桥郡和彼得伯勒国民保健服务基金会信托的数据评估了他们的长期死亡率。我们从诊断之时起研究了死亡风险的时间进程和持续时间。感染SARS-CoV-2后，重症精神疾病患者在最初28天内以及随后的28至60天内死亡风险显著更高（风险比（HR）=5.16，95%置信区间（CI）1.56 - 17.03；P = 0.007），高于未感染者，但60天后额外的死亡风险不再显著（HR = 2.33，95% CI 0.83 - 6.53；P = 0.107）。
