Department of Oral and Cranio-maxillofacial Science, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China.
Institute of Translational Medicine, Shanghai University, Shanghai 200011, China.
J Mater Chem B. 2021 Dec 1;9(46):9505-9513. doi: 10.1039/d1tb01917a.
With the aging population worldwide, osteoporosis, as an age-related bone metabolic disease, is becoming a hot issue in public health. However, it is still a great challenge to realize osteoporotic bone healing due to the alteration of the bone microenvironment in osteoporosis patients. In this study, a nano-structured akermanite (nAK) coating was constructed on Ti-6Al-4V implants to improve osteoporotic bone repair. studies indicated that both the surface nano-topography and bioactive ions released from the nAK coatings promoted the proliferation, osteogenesis, angiogenesis and inhibited osteoclastogenesis of ovariectomy rabbit-derived bone marrow mesenchymal stem cells (OVX-rBMSCs). Furthermore, the nAK-coated Ti-6Al-4V implants improved new bone formation and osseointegration in an osteoporosis rabbit model . These results indicated that the AK coating with a nano-structured surface on the Ti-6Al-4V implant could synergistically promote bone formation and osseointegration for osteoporosis patients. This may be a promising strategy to improve the bone regeneration and osseointegration capability of orthopedic implants under osteoporosis conditions.
随着全球人口老龄化，骨质疏松症作为一种与年龄相关的骨骼代谢疾病，正成为公共卫生领域的一个热点问题。然而，由于骨质疏松症患者骨骼微环境的改变，实现骨质疏松性骨折愈合仍然是一个巨大的挑战。在这项研究中，在 Ti-6Al-4V 植入物上构建了纳米结构的硅灰石（nAK）涂层，以改善骨质疏松性骨修复。研究表明，nAK 涂层的表面纳米形貌和释放的生物活性离子都促进了去卵巢兔源性骨髓间充质干细胞（OVX-rBMSCs）的增殖、成骨、血管生成，并抑制了破骨细胞的生成。此外，nAK 涂层的 Ti-6Al-4V 植入物改善了骨质疏松兔模型中的新骨形成和骨整合。这些结果表明，Ti-6Al-4V 植入物表面的 AK 涂层具有纳米结构，可协同促进骨质疏松患者的骨形成和骨整合。这可能是一种有前途的策略，可改善骨质疏松症条件下骨科植入物的骨再生和骨整合能力。
