Department of Chemistry, Yazd University, Yazd 8915818411, Iran.
Department of Horticultural Sciences, Faculty of Agriculture & Natural Resources, Ardakan University, P.O. Box 184, Ardakan, Iran.
Int J Biol Macromol. 2021 Dec 15;193(Pt B):1972-1985. doi: 10.1016/j.ijbiomac.2021.11.028. Epub 2021 Nov 6.
Natural polymers are an efficient class of eco-friendly and biodegradable polymers, because they are readily available, come from natural sources, inexpensive and can be chemically modified with the correct reagents. Guar gum (GG) is a natural polymer with great potential to be used in pharmaceutical formulations due to its unique composition and lack of toxicity. GG can be designed to suit the needs of the biological and medical engineering sectors. In the development of innovative drug delivery systems, GG is commonly utilized as a rate-controlling excipient. In this review, different properties of GG including chemical composition, extraction methods and its usefulness in diabetes, cholesterol lowering, weight control, tablet formulations as well as its food application were discussed. The other purpose of this study is to evaluate potential use of GG and its derivatives for advanced nanomedicine such as drug delivery, tissue engineering and nanosensing. It should be noted that some applicable patents in medical area have also been included in the rest of this survey to extend knowledge about guar gum and its polymeric nature.
天然聚合物是一类高效的环保型和可生物降解聚合物，因为它们易得、源自天然资源、价格低廉，并且可以用合适的试剂进行化学修饰。瓜尔胶（GG）是一种天然聚合物，由于其独特的组成和无毒特性，具有很大的应用于药物制剂的潜力。可以根据生物和医学工程领域的需求来设计 GG。在创新药物输送系统的开发中，GG 通常被用作控释赋形剂。在本综述中，讨论了 GG 的不同性质，包括化学组成、提取方法及其在糖尿病、降胆固醇、体重控制、片剂制剂以及食品应用方面的用途。本研究的另一个目的是评估 GG 及其衍生物在药物输送、组织工程和纳米传感等先进纳米医学中的潜在用途。值得注意的是，本调查的其余部分还包括一些医疗领域的适用专利，以扩展对瓜尔胶及其聚合性质的了解。
