类固醇硫酸酯酶基因与小鼠性反转突变的连锁关系。
Linkage of the steroid sulfatase gene to the sex-reversed mutation in the mouse.
作者信息
Keitges E A, Schorderet D F, Gartler S M
出版信息
Genetics. 1987 Jul;116(3):465-8. doi: 10.1093/genetics/116.3.465.
Abstract
Dosage studies and the inheritance pattern of the gene for steroid sulfatase (Sts) in the mouse have previously provided indirect evidence for a functional Y-linked allele which recombines obligatorily with its X-linked allele in male meiosis. In this study, we have investigated the linkage relationship of Sts and the sex-reversed mutation (Sxr), a gene which is known to reside in the pairing region of the Y chromosome. The results clearly demonstrate that Sxr and Sts are linked in a region of obligatory recombination and Sts maps proximal to Sxr with most recombinants occurring proximal to the two genes.
摘要
此前，关于小鼠类固醇硫酸酯酶（Sts）基因的剂量研究和遗传模式提供了间接证据，表明存在一个功能性Y连锁等位基因，该等位基因在雄性减数分裂中与其X连锁等位基因必然发生重组。在本研究中，我们研究了Sts与性反转突变（Sxr）的连锁关系，已知Sxr基因位于Y染色体的配对区域。结果清楚地表明，Sxr和Sts在一个必然重组的区域内连锁，并且Sts位于Sxr的近端，大多数重组发生在这两个基因的近端。
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