Schuler L A, Hurley W L
Proc Natl Acad Sci U S A. 1987 Aug;84(16):5650-4. doi: 10.1073/pnas.84.16.5650.
Bovine (Bos taurus) prolactin-related cDNA I (bPRC-I), distinct from the isolated bovine placental lactogen, was derived from bovine fetal placental mRNA by molecular cloning. The nucleotide sequence is 63% homologous to bovine prolactin cDNA and only 45% to bovine growth hormone. The region of bPRC-I corresponding to the 5' portion of the signal peptide and 5' untranslated region of bovine prolactin mRNA is markedly different from prolactin. The predicted protein is 39% homologous to bovine prolactin and about 30% to the related placental hormones in rodents. This identification of a prolactin-related gene in the cow in addition to those reported in rodents suggests that multiple prolactin-related genes expressed in the placenta may be a general phenomenon in nonprimates. The role of these related hormones during gestation remains to be investigated.
与分离出的牛胎盘催乳素不同，牛（Bos taurus）催乳素相关cDNA I（bPRC-I）是通过分子克隆从牛胎儿胎盘mRNA中获得的。其核苷酸序列与牛催乳素cDNA的同源性为63%，与牛生长激素的同源性仅为45%。bPRC-I中与牛催乳素mRNA信号肽5'部分和5'非翻译区相对应的区域与催乳素明显不同。预测的蛋白质与牛催乳素的同源性为39%，与啮齿动物中相关胎盘激素的同源性约为30%。除了在啮齿动物中报道的那些基因外，在牛中鉴定出催乳素相关基因表明，在胎盘中表达的多个催乳素相关基因可能是非灵长类动物中的普遍现象。这些相关激素在妊娠期间的作用仍有待研究。
