Abolghasemi Maryam, Esmaeilzadeh Sedighe, Mirabi Parvaneh, Golsorkhtabaramiri Masoumeh
Student Research Committee, Babol University of Medical Sciences, Babol, Mazandaran, Iran.
Department of Clinical Biochemistry, Babol University of Medical Sciences, Ganjafrooze Avenue, Babol, Mazandaran, Iran.
Int J Prev Med. 2021 Sep 21;12:108. doi: 10.4103/ijpvm.IJPVM_178_19. eCollection 2021.
Endometriosis is one of the gynecological disorders and its prevalence is estimated to 8.10% of reproductive-age women. In Iran, the frequency of endometriosis was reported at 29% among infertile women. The etiology of endometriosis is still unclear. Numerous environmental contaminants such as polychlorinated biphenyls (PCBs) may play important roles in endometriosis development and etiology. Iranian population has relatively low levels of PCBs. However, no studies have evaluated PCBs levels in Iranian endometriosis patients so far. At present, there is no systematic review of the relationship between only PCBs exposure and the risk of endometriosis. The aim of this systematic review and meta-analysis protocol will be to evaluate the association between only PCBs exposure and the risk of endometriosis. PubMed/MEDLINE, Web of Science, Scopus, Google Scholar, Embase, key journals, conferences/congress research papers, and the references of included primary studies will be searched. Observational studies (cross-sectional, case-control, and cohort) in humans that investigated the association between PCBs exposure and the risk of endometriosis will be included. The outcome will be endometriosis risk in association with PCBs exposure. The primary screening and data extraction will be performed by three team members independently and will be judged by opinion with the fourth member. The modified Newcastle-Ottawa Scale (NOS) will be used for the quality assessment of studies. Findings from this study will recognize the association between PCBs exposure and the risk of endometriosis. Results may provide a new window for identifying the role of PCBs as environmental risk factors in relation to the development of endometriosis. PROSPERO; CRD42019120539.
子宫内膜异位症是一种妇科疾病，据估计，其在育龄妇女中的患病率为8.10%。在伊朗，据报道不育女性中子宫内膜异位症的发病率为29%。子宫内膜异位症的病因仍不清楚。多氯联苯（PCBs）等众多环境污染物可能在子宫内膜异位症的发生发展和病因中起重要作用。伊朗人群的多氯联苯水平相对较低。然而，迄今为止尚无研究评估伊朗子宫内膜异位症患者的多氯联苯水平。目前，尚无关于仅多氯联苯暴露与子宫内膜异位症风险之间关系的系统评价。本系统评价和荟萃分析方案的目的是评估仅多氯联苯暴露与子宫内膜异位症风险之间的关联。将检索PubMed/MEDLINE、科学网、Scopus、谷歌学术、Embase、主要期刊、会议/大会研究论文以及纳入的原始研究的参考文献。将纳入调查多氯联苯暴露与子宫内膜异位症风险之间关联的人类观察性研究（横断面研究、病例对照研究和队列研究）。结局将是与多氯联苯暴露相关的子宫内膜异位症风险。初步筛选和数据提取将由三名团队成员独立进行，并由第四名成员进行意见判断。将使用改良的纽卡斯尔-渥太华量表（NOS）对研究进行质量评估。本研究的结果将明确多氯联苯暴露与子宫内膜异位症风险之间的关联。结果可能为确定多氯联苯作为子宫内膜异位症发展相关环境风险因素的作用提供一个新窗口。国际前瞻性系统评价注册库；CRD42019120539。
