Azeez Taoreed Adegoke, Abo-Briggs Tamunosaki, Adeyanju Ayodeji Sylvester
Department of Medicine, Reddington Multi-Specialist Hospital, Lagos, Nigeria.
Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Nigeria.
Indian J Endocrinol Metab. 2021 May-Jun;25(3):182-190. doi: 10.4103/ijem.ijem_301_21. Epub 2021 Oct 26.
Gestational diabetes mellitus (GDM) is any degree of glucose intolerance with onset or first diagnosis in pregnancy. GDM has numerous potential complications and it is important to estimate its burden and risk factors. The objective of the meta-analysis was to determine the pooled prevalence of GDM in Nigeria and identify its determinants.
The study design was a meta-analysis; therefore the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Electronic databases (African Journal Online, PubMed, SCOPUS, and Google Scholar) and the gray literature were systematically searched. Statistical analysis was done with MetaXL using the random effect model. Heterogeneity was determined using the I statistic and the publication bias was checked with the Doi plot.
The total sample size was 46 210. The prevalence of GDM in Nigeria was 0.5 - 38% and the pooled prevalence was 11.0% (95% CI 8-13). The I statistic was 99%. The Doi plot suggested some degree of bias. The most frequently reported determinants of GDM were previous macrosomic babies, maternal obesity, family history of diabetes, previous miscarriage, and advanced maternal age.
The prevalence of GDM in Nigeria is high and efforts should be geared at modifying its risk factors so as to reduce its prevalence and prevent the associated complications.
妊娠期糖尿病（GDM）是指在孕期出现或首次诊断的任何程度的葡萄糖不耐受。GDM有许多潜在并发症，评估其负担和风险因素很重要。本荟萃分析的目的是确定尼日利亚GDM的合并患病率并识别其决定因素。
研究设计为荟萃分析；因此遵循系统评价和荟萃分析的首选报告项目（PRISMA）指南。系统检索了电子数据库（非洲期刊在线、PubMed、SCOPUS和谷歌学术）以及灰色文献。使用MetaXL采用随机效应模型进行统计分析。使用I统计量确定异质性，并通过Doi图检查发表偏倚。
总样本量为46210。尼日利亚GDM的患病率为0.5%-38%，合并患病率为11.0%（95%CI 8-13）。I统计量为99%。Doi图显示存在一定程度的偏倚。最常报告的GDM决定因素是既往巨大儿、母亲肥胖、糖尿病家族史、既往流产和高龄产妇。
尼日利亚GDM的患病率很高，应努力改变其风险因素，以降低其患病率并预防相关并发症。
