• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

绞股蓝皂苷 XVII 通过抑制内质网应激诱导的线粒体损伤来保护心肌缺血再灌注损伤。

Gypenoside XVII protects against myocardial ischemia and reperfusion injury by inhibiting ER stress-induced mitochondrial injury.

作者信息

Yu Yingli, Wang Min, Chen Rongchang, Sun Xiao, Sun Guibo, Sun Xiaobo

机构信息

Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China.

出版信息

J Ginseng Res. 2021 Nov;45(6):642-653. doi: 10.1016/j.jgr.2019.09.003. Epub 2019 Nov 14.

DOI:10.1016/j.jgr.2019.09.003
PMID:34764719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8569261/
Abstract

BACKGROUND

Effective strategies are dramatically needed to prevent and improve the recovery from myocardial ischemia and reperfusion (I/R) injury. Direct interactions between the mitochondria and endoplasmic reticulum (ER) during heart diseases have been recently investigated. This study was designed to explore the cardioprotective effects of gypenoside XVII (GP-17) against I/R injury. The roles of ER stress, mitochondrial injury, and their crosstalk within I/R injury and in GP-17-induced cardioprotection are also explored.

METHODS

Cardiac contractility function was recorded in Langendorff-perfused rat hearts. The effects of GP-17 on mitochondrial function including mitochondrial permeability transition pore opening, reactive oxygen species production, and respiratory function were determined using fluorescence detection kits on mitochondria isolated from the rat hearts. H9c2 cardiomyocytes were used to explore the effects of GP-17 on hypoxia/reoxygenation.

RESULTS

We found that GP-17 inhibits myocardial apoptosis, reduces cardiac dysfunction, and improves contractile recovery in rat hearts. Our results also demonstrate that apoptosis induced by I/R is predominantly mediated by ER stress and associated with mitochondrial injury. Moreover, the cardioprotective effects of GP-17 are controlled by the PI3K/AKT and P38 signaling pathways.

CONCLUSION

GP-17 inhibits I/R-induced mitochondrial injury by delaying the onset of ER stress through the PI3K/AKT and P38 signaling pathways.

摘要

背景

迫切需要有效的策略来预防和改善心肌缺血再灌注（I/R）损伤后的恢复。近年来，人们对心脏病期间线粒体与内质网（ER）之间的直接相互作用进行了研究。本研究旨在探讨绞股蓝皂苷XVII（GP-17）对I/R损伤的心脏保护作用。还探讨了内质网应激、线粒体损伤及其在I/R损伤和GP-17诱导的心脏保护中的相互作用。

方法

在Langendorff灌注的大鼠心脏中记录心脏收缩功能。使用荧光检测试剂盒对从大鼠心脏分离的线粒体，测定GP-17对线粒体功能的影响，包括线粒体通透性转换孔开放、活性氧生成和呼吸功能。使用H9c2心肌细胞探讨GP-17对缺氧/复氧的影响。

结果

我们发现GP-17可抑制大鼠心脏的心肌细胞凋亡，减轻心脏功能障碍，并改善收缩恢复。我们的结果还表明，I/R诱导的凋亡主要由内质网应激介导，并与线粒体损伤有关。此外，GP-17的心脏保护作用受PI3K/AKT和P38信号通路调控。

结论

GP-17通过PI3K/AKT和P38信号通路延迟内质网应激的发生，从而抑制I/R诱导的线粒体损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/ad54e795753f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/60dfab3c3af3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/59624ed73dc0/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/4407d528a111/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/453b51af7944/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/a0ec16892378/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/906f20b8843f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/ad54e795753f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/60dfab3c3af3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/59624ed73dc0/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/4407d528a111/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/453b51af7944/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/a0ec16892378/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/906f20b8843f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/8569261/ad54e795753f/gr7.jpg

相似文献

1
Gypenoside XVII protects against myocardial ischemia and reperfusion injury by inhibiting ER stress-induced mitochondrial injury.绞股蓝皂苷 XVII 通过抑制内质网应激诱导的线粒体损伤来保护心肌缺血再灌注损伤。
J Ginseng Res. 2021 Nov;45(6):642-653. doi: 10.1016/j.jgr.2019.09.003. Epub 2019 Nov 14.
2
Cardioprotective effects of gypenoside XVII against ischemia/reperfusion injury: Role of endoplasmic reticulum stress, autophagy, and mitochondrial fusion fission balance.绞股蓝皂苷 XVII 对缺血/再灌注损伤的心脏保护作用：内质网应激、自噬以及线粒体融合分裂平衡的作用。
Phytother Res. 2022 Jul;36(7):2982-2998. doi: 10.1002/ptr.7493. Epub 2022 May 27.
3
Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro.绞股蓝皂苷通过在体内和体外抑制CHOP通路并激活PI3K/Akt通路来抑制心肌细胞凋亡，从而保护心肌缺血再灌注损伤。
Cell Physiol Biochem. 2016;39(1):123-36. doi: 10.1159/000445611. Epub 2016 Jun 20.
4
Zn and mPTP Mediate Endoplasmic Reticulum Stress Inhibition-Induced Cardioprotection Against Myocardial Ischemia/Reperfusion Injury.锌与线粒体通透性转换孔介导内质网应激抑制诱导的心肌缺血/再灌注损伤心脏保护作用。
Biol Trace Elem Res. 2016 Nov;174(1):189-197. doi: 10.1007/s12011-016-0707-2. Epub 2016 Apr 23.
5
Tournefolic acid B, derived from Clinopodium chinense (Benth.) Kuntze, protects against myocardial ischemia/reperfusion injury by inhibiting endoplasmic reticulum stress-regulated apoptosis via PI3K/AKT pathways.旋覆花酸 B 来源于荆芥（Benth.）Kuntze，通过抑制内质网应激调节的凋亡途径 PI3K/AKT 来保护心肌缺血/再灌注损伤。
Phytomedicine. 2019 Jan;52:178-186. doi: 10.1016/j.phymed.2018.09.168. Epub 2018 Oct 2.
6
Remifentanil Induces Cardio Protection Against Ischemia/Reperfusion Injury by Inhibiting Endoplasmic Reticulum Stress Through the Maintenance of Zinc Homeostasis.瑞芬太尼通过维持锌稳态抑制内质网应激诱导心肌缺血/再灌注损伤保护作用。
Anesth Analg. 2018 Jul;127(1):267-276. doi: 10.1213/ANE.0000000000003414.
7
Gypenoside XVII attenuates renal ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-triggered pyroptosis.绞股蓝皂苷 XVII 通过抑制内质网应激和 NLRP3 炎性体触发的细胞焦亡减轻肾缺血再灌注损伤。
Eur J Pharmacol. 2024 Jan 5;962:176187. doi: 10.1016/j.ejphar.2023.176187. Epub 2023 Nov 19.
8
Nerve growth factor protects the ischemic heart via attenuation of the endoplasmic reticulum stress induced apoptosis by activation of phosphatidylinositol 3-kinase.神经生长因子通过激活磷脂酰肌醇3激酶减轻内质网应激诱导的细胞凋亡，从而保护缺血心脏。
Int J Med Sci. 2015 Jan 1;12(1):83-91. doi: 10.7150/ijms.10101. eCollection 2015.
9
TGF-β improves myocardial function and prevents apoptosis induced by anoxia-reoxygenation, through the reduction of endoplasmic reticulum stress.转化生长因子-β通过减轻内质网应激来改善心肌功能并防止缺氧复氧诱导的细胞凋亡。
Can J Physiol Pharmacol. 2016 Jan;94(1):9-17. doi: 10.1139/cjpp-2014-0466. Epub 2015 Jun 11.
10
Globular adiponectin attenuates myocardial ischemia/reperfusion injury by upregulating endoplasmic reticulum Ca²⁺-ATPase activity and inhibiting endoplasmic reticulum stress.球形脂联素通过上调内质网 Ca²⁺-ATP 酶活性和抑制内质网应激来减轻心肌缺血/再灌注损伤。
J Cardiovasc Pharmacol. 2013 Aug;62(2):143-53. doi: 10.1097/FJC.0b013e31829521af.

引用本文的文献

1
Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury.药食同源物质及中药植物化学物对急性肾损伤的肾保护作用
Front Pharmacol. 2025 Feb 19;16:1539886. doi: 10.3389/fphar.2025.1539886. eCollection 2025.
2
Mitochondria and myocardial ischemia/reperfusion injury: Effects of Chinese herbal medicine and the underlying mechanisms.线粒体与心肌缺血/再灌注损伤：中草药的作用及其潜在机制
J Pharm Anal. 2025 Feb;15(2):101051. doi: 10.1016/j.jpha.2024.101051. Epub 2024 Jul 23.
3
Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury.

本文引用的文献

1
Endoplasmic reticulum stress induces cardiac dysfunction through architectural modifications and alteration of mitochondrial function in cardiomyocytes.内质网应激通过心肌细胞的结构改变和线粒体功能改变诱导心脏功能障碍。
Cardiovasc Res. 2019 Feb 1;115(2):328-342. doi: 10.1093/cvr/cvy197.
2
The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress.未折叠蛋白反应的 PERK 臂在急性内质网应激期间调节线粒体形态。
Cell Rep. 2018 Mar 13;22(11):2827-2836. doi: 10.1016/j.celrep.2018.02.055.
3
Rosuvastatin postconditioning protects isolated hearts against ischemia-reperfusion injury: The role of radical oxygen species, PI3K-Akt-GSK-3β pathway, and mitochondrial permeability transition pore.
天然药物调节内质网应激在心肌损伤治疗中的潜力。
J Pharm Anal. 2024 Nov;14(11):101034. doi: 10.1016/j.jpha.2024.101034. Epub 2024 Jul 2.
4
Gypenosides exert cardioprotective effects by promoting mitophagy and activating PI3K/Akt/GSK-3/Mcl-1 signaling.绞股蓝总苷通过促进线粒体自噬和激活 PI3K/Akt/GSK-3/Mcl-1 信号通路发挥心脏保护作用。
PeerJ. 2024 Jun 20;12:e17538. doi: 10.7717/peerj.17538. eCollection 2024.
5
Gypenoside XVII Reduces Synaptic Glutamate Release and Protects against Excitotoxic Injury in Rats.绞股蓝皂苷 XVII 减少突触谷氨酸释放并保护大鼠免受兴奋性毒性损伤。
Biomolecules. 2024 May 16;14(5):589. doi: 10.3390/biom14050589.
6
Berberine inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via the RhoE/AMPK pathway.小檗碱通过 RhoE/AMPK 通路抑制过度自噬，保护心肌免受缺血/再灌注损伤。
Int J Mol Med. 2024 May;53(5). doi: 10.3892/ijmm.2024.5373. Epub 2024 Apr 5.
7
Natural Products Targeting PI3K/AKT in Myocardial Ischemic Reperfusion Injury: A Scoping Review.靶向PI3K/AKT治疗心肌缺血再灌注损伤的天然产物：一项范围综述
Pharmaceuticals (Basel). 2023 May 12;16(5):739. doi: 10.3390/ph16050739.
8
Ginsenosides from as Key Modulators of NF-κB Signaling Are Powerful Anti-Inflammatory and Anticancer Agents.三七总皂苷作为 NF-κB 信号通路的关键调节剂，是一种强大的抗炎和抗癌药物。
Int J Mol Sci. 2023 Mar 24;24(7):6119. doi: 10.3390/ijms24076119.
9
Protective effects of Gypenoside XVII against cerebral ischemia/reperfusion injury via SIRT1-FOXO3A- and Hif1a-BNIP3-mediated mitochondrial autophagy.绞股蓝皂苷 XVII 通过 SIRT1-FOXO3A- 和 Hif1a-BNIP3 介导的线粒体自噬对脑缺血/再灌注损伤的保护作用。
J Transl Med. 2022 Dec 27;20(1):622. doi: 10.1186/s12967-022-03830-9.
10
The anti-aging effects of Renshen Guben on thyrotoxicosis mice: Improving immunosenescence, hypoproteinemia, lipotoxicity, and intestinal flora.人参固本对甲亢小鼠的抗衰老作用：改善免疫衰老、低蛋白血症、脂毒性和肠道菌群。
Front Immunol. 2022 Oct 25;13:983501. doi: 10.3389/fimmu.2022.983501. eCollection 2022.
瑞舒伐他汀后处理可保护离体心脏免受缺血再灌注损伤：活性氧、PI3K-Akt-GSK-3β信号通路及线粒体通透性转换孔的作用
Cardiovasc Ther. 2017 Feb;35(1):3-9. doi: 10.1111/1755-5922.12225.
4
Pharmacological Management of Chronic Stable Angina: Focus on Ranolazine.慢性稳定性心绞痛的药物治疗：聚焦于雷诺嗪
Cardiovasc Drugs Ther. 2016 Aug;30(4):393-398. doi: 10.1007/s10557-016-6674-1.
5
Ranolazine Therapy in Cardiac Arrhythmias.雷诺嗪治疗心律失常
Pacing Clin Electrophysiol. 2016 Sep;39(9):1006-15. doi: 10.1111/pace.12905. Epub 2016 Jul 23.
6
Gypenoside XVII Enhances Lysosome Biogenesis and Autophagy Flux and Accelerates Autophagic Clearance of Amyloid-β through TFEB Activation.绞股蓝皂苷 XVII 通过激活转录因子 EB（TFEB）增强溶酶体生物合成和自噬通量，并加速淀粉样β蛋白的自噬清除。
J Alzheimers Dis. 2016 Apr 5;52(3):1135-50. doi: 10.3233/JAD-160096.
7
The impact of cardiac ischemia/reperfusion on the mitochondria-cytoskeleton interactions.心脏缺血/再灌注对线粒体-细胞骨架相互作用的影响。
Biochim Biophys Acta. 2016 Jun;1862(6):1159-71. doi: 10.1016/j.bbadis.2016.03.009. Epub 2016 Mar 11.
8
Cardioprotective effects of Notoginsenoside R1 against ischemia/reperfusion injuries by regulating oxidative stress- and endoplasmic reticulum stress- related signaling pathways.三七皂苷R1通过调节氧化应激和内质网应激相关信号通路对缺血/再灌注损伤的心脏保护作用。
Sci Rep. 2016 Feb 18;6:21730. doi: 10.1038/srep21730.
9
Activation of large-conductance Ca(2+)-activated K(+) channels inhibits glutamate-induced oxidative stress through attenuating ER stress and mitochondrial dysfunction.大电导钙激活钾通道的激活通过减轻内质网应激和线粒体功能障碍来抑制谷氨酸诱导的氧化应激。
Neurochem Int. 2015 Nov;90:28-35. doi: 10.1016/j.neuint.2015.07.004. Epub 2015 Jul 7.
10
Ca(2+) homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling.钙离子稳态与内质网应激：钙信号的综合观点
Biochem Biophys Res Commun. 2015 Apr 24;460(1):114-21. doi: 10.1016/j.bbrc.2015.02.004.