上转换纳米粒子表面工程 DNA 用于生物分析和治疗。
Engineering DNA on the Surface of Upconversion Nanoparticles for Bioanalysis and Therapeutics.
机构信息
The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China.
出版信息
ACS Nano. 2021 Nov 23;15(11):17257-17274. doi: 10.1021/acsnano.1c08036. Epub 2021 Nov 12.
Surface modification of inorganic nanomaterials with biomolecules has enabled the development of composites integrated with extensive properties. Lanthanide ion-doped upconversion nanoparticles (UCNPs) are one class of inorganic nanomaterials showing optical properties that convert photons of lower energy into higher energy. Additionally, DNA oligonucleotides have exhibited powerful capabilities for organizing various nanomaterials with versatile topological configurations. Through rational design and nanotechnology, DNA-based UCNPs offer predesigned functionality and potential. To fully harness the capabilities of UCNPs integrated with DNA, various DNA-UCNP composites have been developed for diagnosis and therapeutics. In this review, beginning with the introduction of the UCNPs and the conjugation of DNA strands on the surface of UCNPs, we present an overview of the recent progress of DNA-UCNP composites while focusing on their applications for bioanalysis and therapeutics.
通过将生物分子修饰到无机纳米材料的表面，使得整合了广泛性能的复合材料得以发展。镧系离子掺杂的上转换纳米粒子（UCNPs）是一类具有将低能量光子转化为高能量光子的光学性能的无机纳米材料。此外，DNA 寡核苷酸已经表现出了用于组织各种纳米材料的强大能力，这些纳米材料具有多种拓扑结构。通过合理的设计和纳米技术，基于 DNA 的 UCNPs 提供了预设的功能和潜力。为了充分利用与 DNA 整合的 UCNPs 的能力，已经开发了各种用于诊断和治疗的 DNA-UCNP 复合材料。在这篇综述中，我们从 UCNPs 的介绍以及 DNA 链在 UCNPs 表面的连接开始，概述了 DNA-UCNP 复合材料的最新进展，同时重点介绍了它们在生物分析和治疗方面的应用。
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