Wang Dongya, Qin Jingcan, Zhang Chuan, Li Yuehua
Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yi Shan Road, Shanghai 200233, China.
School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Nanomaterials (Basel). 2022 Sep 27;12(19):3383. doi: 10.3390/nano12193383.
Black phosphorus nanomaterials (BPN) have been well developed in tumor therapy. However, lack of diagnostic function limits the development of BPN in biomedicine. Lanthanide-doped nanoparticles are considered as versatile materials for fluorescence or magnetic resonance imaging. Integration of BPN with lanthanide-doped nanoparticles was rarely reported owing to the complex synthesis processes and poor modification effect. Herein, we report a simple and general method for synthesizing BPN@NaReF (Re: Gd or Y, Yb, Er) nanocomposite. TEM and XRD characterization confirm efficient combination of BPN and NaGdF or NaYF:Yb,Er (18.2 mol %) after one-step mixing. The FTIR and XPS spectra were used to prove the generation of PO-Gd and P-Gd coordination bonds and clarify ligand exchange mechanism. The anchored nanoparticles on BPN were stable and become hydrophilic. The prepared BPN@NaGdF exhibit the signals of photoacoustic and magnetic resonance imaging. The obtained BPN@NaYF:Yb,Er (18.2 mol %) have the potential in fluorescence bioimaging. We believe that this work will expand the applications of BPN in diagnosis and therapy together.
黑磷纳米材料（BPN）在肿瘤治疗方面已得到充分发展。然而，缺乏诊断功能限制了BPN在生物医学中的发展。镧系元素掺杂的纳米粒子被认为是用于荧光或磁共振成像的多功能材料。由于合成过程复杂且修饰效果不佳，BPN与镧系元素掺杂的纳米粒子的整合鲜有报道。在此，我们报道了一种简单通用的方法来合成BPN@NaReF（Re：Gd或Y、Yb、Er）纳米复合材料。透射电子显微镜（TEM）和X射线衍射（XRD）表征证实了一步混合后BPN与NaGdF或NaYF:Yb,Er（18.2摩尔%）的有效结合。傅里叶变换红外光谱（FTIR）和X射线光电子能谱（XPS）用于证明PO-Gd和P-Gd配位键的生成，并阐明配体交换机制。BPN上锚定的纳米粒子稳定且具有亲水性。制备的BPN@NaGdF表现出光声和磁共振成像信号。所获得的BPN@NaYF:Yb,Er（18.2摩尔%）在荧光生物成像方面具有潜力。我们相信这项工作将共同拓展BPN在诊断和治疗中的应用。
