细胞衰老过程中mRNA的N6-甲基腺苷甲基化
N6-Methyladenosine Methylation of mRNA in Cell Senescence.
作者信息
Zhang Lin, Xia Jian
机构信息
Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Clinical Research Center for Cerebrovascular Disease of Hunan Province, Central South University, Changsha, Hunan, China.
出版信息
Cell Mol Neurobiol. 2023 Jan;43(1):27-36. doi: 10.1007/s10571-021-01168-2. Epub 2021 Nov 12.
Cell senescence is the growth arrest caused by the accumulation of irreparable cell damage, which is involved in physiological and pathological processes and regulated by the post-transcriptional level. This regulation is performed by transcriptional regulators and driven by aging-related small RNAs, long non-coding RNAs, and RNA-binding proteins. N6-methyladenosine (mA) is the most common chemical modification in eukaryotic mRNA, which can enhance or reduce the binding of transcriptional regulators. Increasing studies have confirmed the crucial role of mA in controlling mRNA in various physiological processes. Remarkably, recent reports have indicated that abnormal methylation of mA-related RNA may affect cell senescence. In this review, we clarified the association between mA modification and cell senescence and analyzed the limitations of the current research.
细胞衰老为由不可修复的细胞损伤积累导致的生长停滞，其参与生理和病理过程，并受转录后水平调控。这种调控由转录调节因子执行，并由衰老相关的小RNA、长链非编码RNA和RNA结合蛋白驱动。N6-甲基腺苷（m6A）是真核生物mRNA中最常见的化学修饰，其可增强或降低转录调节因子的结合。越来越多的研究证实了m6A在各种生理过程中控制mRNA的关键作用。值得注意的是，最近的报告表明，与m6A相关的RNA的异常甲基化可能影响细胞衰老。在本综述中，我们阐明了m6A修饰与细胞衰老之间的关联，并分析了当前研究的局限性。
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