Guerrero-Gironés Julia, Ros-Valverde Antonio, Pecci-Lloret María Pilar, Rodríguez-Lozano Francisco Javier, Pecci-Lloret Miguel Ramón
Special Care Dentistry and Gerodontology Unit, School of Medicine and Dentistry, IMIB-Arrixaca, University of Murcia, 30100 Murcia, Spain.
J Clin Med. 2021 Oct 23;10(21):4886. doi: 10.3390/jcm10214886.
Several studies have linked apical periodontitis and systemic diseases. The aim of this study is to present a systematic review of the available literature investigating whether there is an association between pulpal-periapical pathology and autoimmune disease. The review was conducted following the PRISMA statement. A literature search was performed in five databases. Studies involving patients with pulpal-periapical pathology and autoimmune diseases were included in the review. Based on the PICO model, the research question aimed to assess whether there is an increased risk of developing pulpal-periapical pathology in patients with autoimmune disease. Article selection, data extraction, and quality assessment were performed using an adapted version of the STROBE guidelines. A total of seven studies were included in our review. The types of articles were five case-control and two cross-sectional studies. Periapical pathologies were associated to three autoimmune diseases (diabetes mellitus I, rheumatoid arthritis, and inflammatory bowel disease). Among the included studies, four show a low risk of bias, while three present a moderate risk. There could be an association between apical periodontitis and autoimmune diseases, although most studies report statistically non-significant associations.
多项研究已将根尖周炎与全身性疾病联系起来。本研究的目的是对现有文献进行系统综述，以调查牙髓-根尖周病变与自身免疫性疾病之间是否存在关联。该综述是按照PRISMA声明进行的。在五个数据库中进行了文献检索。涉及牙髓-根尖周病变患者和自身免疫性疾病患者的研究被纳入该综述。基于PICO模型，研究问题旨在评估自身免疫性疾病患者发生牙髓-根尖周病变的风险是否增加。文章选择、数据提取和质量评估是使用STROBE指南的改编版本进行的。我们的综述共纳入了七项研究。文章类型为五项病例对照研究和两项横断面研究。根尖周病变与三种自身免疫性疾病（I型糖尿病、类风湿性关节炎和炎症性肠病）相关。在所纳入的研究中，四项显示出低偏倚风险，而三项呈现出中度风险。根尖周炎与自身免疫性疾病之间可能存在关联，尽管大多数研究报告的关联在统计学上不显著。
