革兰氏阴性菌能否对抗菌蓝光治疗产生耐药性？
Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
机构信息
Department of Pharmaceutical Microbiology, The Faculty of Pharmacy, Medical University of Gdansk, Hallera 107, 80-416 Gdansk, Poland.
Laboratory of Photobiology and Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland.
出版信息
Int J Mol Sci. 2021 Oct 27;22(21):11579. doi: 10.3390/ijms222111579.
Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential of tolerance/resistance development in , , and and demonstrated that representative Gram-negative bacteria may develop tolerance to aBL. The observed adaption was a stable feature. Assays involving K-12 -, , , and -deficient mutants revealed some possible mechanisms for aBL tolerance development.
抗菌蓝光（aBL）治疗因其多靶点作用模式被认为发展细菌耐药性和耐受性的风险较低。本研究旨在证明革兰氏阴性菌是否会产生耐药性。我们评估了 、 、 和 中耐药/耐受性发展的潜力，并表明代表性革兰氏阴性菌可能对 aBL 产生耐药性。观察到的适应是一个稳定的特征。涉及 K-12 、 、 、 和 -缺陷突变体的实验揭示了 aBL 耐药性发展的一些可能机制。
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