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聚酰胺-胺型杯芳烃树枝状大分子：合成及硫代杯芳烃构象对DNA结合的影响

PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding.

作者信息

Mostovaya Olga, Padnya Pavel, Shiabiev Igor, Mukhametzyanov Timur, Stoikov Ivan

机构信息

A.M. Butlerov' Chemistry Institute, Kazan Federal University, 420008 Kazan, Russia.

出版信息

Int J Mol Sci. 2021 Nov 2;22(21):11901. doi: 10.3390/ijms222111901.

DOI:10.3390/ijms222111901
PMID:34769329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8585033/
Abstract

A convenient method for the synthesis of the first generation PAMAM dendrimers based on the thiacalix[4]arene has been developed for the first time. Three new PAMAM-calix-dendrimers with the macrocyclic core in , , and conformations were obtained with high yields. The interaction of the obtained compounds with salmon sperm DNA resulted in the formation of the associates of the size up to 200 nm, as shown by the UV-Vis spectroscopy, DLS, and TEM. It was demonstrated by the CD method that the structure of the DNA did not undergo significant changes upon binding. The PAMAM-calix-dendrimer based on the macrocycle in conformation stabilized DNA and prevented its degradation.

摘要

首次开发了一种基于硫杂杯[4]芳烃合成第一代聚酰胺-胺（PAMAM）树枝状大分子的简便方法。获得了三种具有大环核处于、和构象的新型PAMAM-杯芳烃树枝状大分子，产率很高。紫外-可见光谱、动态光散射（DLS）和透射电子显微镜（TEM）表明，所得化合物与鲑鱼精DNA相互作用形成了尺寸达200 nm的聚集体。圆二色（CD）法表明，结合后DNA的结构没有发生显著变化。基于构象大环的PAMAM-杯芳烃树枝状大分子使DNA稳定并防止其降解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0048/8585033/fb229ed02376/ijms-22-11901-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0048/8585033/1e5a9fe9bea9/ijms-22-11901-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0048/8585033/bc5ca6debcfa/ijms-22-11901-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0048/8585033/fb229ed02376/ijms-22-11901-g006.jpg

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