Department of Microbiology, Panjab University, Chandigarh, 160014, India.
Department of Biotechnology, Panjab University, Chandigarh, India.
Environ Sci Pollut Res Int. 2022 Jan;29(3):3355-3371. doi: 10.1007/s11356-021-17374-w. Epub 2021 Nov 12.
The overuse of antibiotics and their disposal without processing are leading the environment and its inhabitants towards a serious health emergency. There is abundance of diverse antibiotic resistance genes and bacteria in environment, which demands immediate attention for the effective removal of antibiotics. There are physical and chemical methods for removal, but the generation of toxic byproducts has directed the efforts towards bioremediation for eco-friendly and sustainable elimination of antibiotics from the environment. Various effective and reliable bioremediation approaches have been used, but still antibiotic residues pose a major global threat. Recent developments in molecular and synthetic biology might offer better solution for engineering of microbe-metabolite biodevices and development of novel strains endowed with desirable properties. This review summarizes the impact of antibiotics on environment, mechanisms of resistance development, and different bioremediation approaches.
抗生素的过度使用及其未经处理的处置正导致环境及其居民面临严重的健康紧急情况。环境中存在大量不同的抗生素耐药基因和细菌，这要求立即关注有效去除抗生素。有物理和化学方法可以去除，但有毒副产物的产生促使人们努力进行生物修复，以实现从环境中去除抗生素的环保和可持续目标。已经使用了各种有效和可靠的生物修复方法，但抗生素残留仍然构成重大的全球威胁。分子和合成生物学的最新发展可能为微生物-代谢物生物器件的工程设计和具有理想特性的新型菌株的开发提供更好的解决方案。本文综述了抗生素对环境的影响、耐药性发展的机制以及不同的生物修复方法。
