National Biosafety Laboratory, Chinese Academy of Sciences, Wuhan 430020, People's Republic of China.
Wuhan Institute of Virology, Chinese Academy of Sciences. Wuhan 430020, People's Republic of China.
Am J Infect Control. 2022 Mar;50(3):319-324. doi: 10.1016/j.ajic.2021.10.035. Epub 2021 Nov 12.
The recent COVID-19 pandemic highlights the need for efficacious virucidal products to limit the spread of SARS-CoV-2. Several studies have suggested that alcohol-based sanitizers and some disinfectants are effective. While virucidal activity data of low-level disinfectants are lacking and some conclusions are not clear yet.
We evaluated the virucidal activity of 2 quaternary ammonium compounds (QAC) disinfectants (MICRO-CHEM PLUS and FWD), W30 (an amphoteric surfactant), and Medical EtOH against SARS-CoV-2. Suspension tests covering different concentration and contact time were performed using the integrated cell culture-qPCR method.
Each of disinfectants was effective at inactivating SARS-CoV-2. MCP and FWD are highly effective within 15 seconds. W30 is also efficient within 2 minutes at concentration of 1%. Consistent with previous report, our results also demonstrated that 38% ethanol was sufficient to completely inactivate virus, which proved the method used in this study is feasible.
QAC disinfectants, MCP and FWD, are highly effective for the inactivation of SARS-CoV-2, which making them practical for use in health care setting and laboratories where prompt disinfection is important. The low-level disinfectant based on amphoteric surfactant, W30, which may present in commonly available household hygiene agents is also able to inactivate SARS-CoV-2.
最近的 COVID-19 大流行凸显了需要有效的杀病毒产品来限制 SARS-CoV-2 的传播。几项研究表明，含酒精的消毒剂和一些消毒剂是有效的。虽然缺乏低水平消毒剂的杀病毒活性数据，并且一些结论尚不清楚。
我们评估了 2 种季铵盐化合物（QAC）消毒剂（MICRO-CHEM PLUS 和 FWD）、W30（一种两性表面活性剂）和医用乙醇对 SARS-CoV-2 的杀病毒活性。使用集成细胞培养-qPCR 方法进行了涵盖不同浓度和接触时间的悬浮试验。
每种消毒剂都能有效灭活 SARS-CoV-2。MCP 和 FWD 在 15 秒内高度有效。W30 在 1%浓度下也在 2 分钟内有效。与之前的报告一致，我们的结果还表明，38%乙醇足以完全灭活病毒，这证明了本研究中使用的方法是可行的。
QAC 消毒剂 MCP 和 FWD 对 SARS-CoV-2 的灭活非常有效，这使得它们在医疗保健环境和实验室中非常实用，在这些环境和实验室中，迅速消毒很重要。基于两性表面活性剂的低水平消毒剂 W30 也能够灭活 SARS-CoV-2，它可能存在于常见的家用卫生用品中。
