in Nepali hospitals: poor outcomes amid 10 years of increasing antimicrobial resistance.

OBJECTIVE

To determine antimicrobial resistance patterns and prevalence of multi- (MDR, i.e., resistant to ⩾3 classes of antimicrobial agents) and extensively (XDR, i.e., resistant to ⩾3, susceptible to ⩽2 groups of antibiotics) drug-resistant strains of .

METHODS

This was a cross-sectional study conducted in Nepal Mediciti Hospital, Lalitpur, Nepal, using standard microbiological methods with Kirby Bauer disc diffusion to identify antimicrobial susceptibility.

RESULTS

( = 447) were most frequently isolated in respiratory ( = 203, 45.4%) and urinary samples ( = 120, 26.8%). AWaRe Access antibiotics showed 25-30% resistance, Watch antibiotics 30-55%. Susceptibility to AWaRe Reserve antibiotics remains high; however, 32.8% were resistant to aztreonam. Overall, 190 (42.5%) were MDR and 99 (22.1%) XDR (first Nepali report) based on mainly non-respiratory samples. The majority of infected patients were >40 years ( = 229, 63.2%) or inpatients ( = 181, 50.0%); 36 (15.2%) had an unfavourable outcome, including death ( = 25, 10.5%). Our larger study showed a failure of improvement over eight previous studies covering 10 years.

CONCLUSION

Antibiotic resistance in occurred to all 19 AWaRe group antibiotics tested. Vulnerable patients are at significant risk from such resistant strains, with a high death rate. Sustainable and acceptable antibiotic surveillance and control are urgently needed across Nepal, as antimicrobial resistance has deteriorated over the last decade.