瞬态模式光热光学相干断层扫描。
Transient-mode photothermal optical coherence tomography.
出版信息
Opt Lett. 2021 Nov 15;46(22):5703-5706. doi: 10.1364/OL.443987.
Abstract
Photothermal optical coherence tomography (PT-OCT) is an emerging extension of OCT, which forms images based on both scattering and absorption of light. The speed of PT-OCT, however, has been limited by the necessity for lock-in detection with extensive temporal sampling of the sample's PT response. Here, we demonstrate transient-mode PT-OCT (TM-PT-OCT), which increases the effective A-line rate by orders of magnitude from 10-100 Hz to 1.5-7.5 kHz, by interrogating the sample's transient thermal response to a single diode laser pulse. Functional imaging of moving samples with TM-PT-OCT at video rate is also presented. This significant improvement in imaging speed is expected to open the door for downstream integration of PT-OCT in clinical systems for in vivo imaging.
摘要
光热光学相干断层扫描（PT-OCT）是 OCT 的一种新兴扩展，它基于光的散射和吸收形成图像。然而，PT-OCT 的速度受到限制，因为需要进行锁相检测，并且需要对样品的 PT 响应进行广泛的时间采样。在这里，我们展示了瞬态模式光热光学相干断层扫描（TM-PT-OCT），通过对单个二极管激光脉冲的样品瞬态热响应进行询问，将有效 A 线速率从 10-100 Hz 提高到 1.5-7.5 kHz，提高了几个数量级。还介绍了 TM-PT-OCT 在视频速率下对移动样品的功能成像。这种成像速度的显著提高有望为在体内成像的临床系统中集成 PT-OCT 打开大门。
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