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经闪光诱导评估调制幅度经颅交流电刺激(AM-TACS)的疗效。

Amplitude modulated transcranial alternating current stimulation (AM-TACS) efficacy evaluation via phosphene induction.

机构信息

Department of Neurology, Otto-Von-Guericke-Universität, Universitätsklinikum Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.

Center for Behavioral Brain Sciences (CBBS), Otto-Von-Guericke-Universität Magdeburg, 39120, Magdeburg, Germany.

出版信息

Sci Rep. 2021 Nov 15;11(1):22245. doi: 10.1038/s41598-021-01482-1.

Abstract

Amplitude modulated transcranial alternating current stimulation (AM-tACS) is a novel method of electrostimulation which enables the recording of electrophysiological signals during stimulation, thanks to an easier removable stimulation artefact compared to classical electrostimulation methods. To gauge the neuromodulatory potential of AM-tACS, we tested its capacity to induce phosphenes as an indicator of stimulation efficacy. AM-tACS was applied via a two-electrode setup, attached on FpZ and below the right eye. AM-tACS waveforms comprised of different carrier (50 Hz, 200 Hz, 1000 Hz) and modulation frequencies (8 Hz, 16 Hz, 28 Hz) were administered with at maximum 2 mA peak-to-peak stimulation strength. TACS conditions in the same frequencies were used as a benchmark for phosphene induction. AM-tACS conditions using a 50 Hz carrier frequency were able to induce phosphenes, but with no difference in phosphene thresholds between modulation frequencies. AM-tACS using a 200 Hz or 1000 Hz carrier frequency did not induce phosphenes. TACS conditions induced phosphenes in line with previous studies. Stimulation effects of AM-tACS conditions were independent of amplitude modulation and instead relied solely on the carrier frequency. A possible explanation may be that AM-tACS needs higher stimulation intensities for its amplitude modulation to have a neuromodulatory effect.

摘要

调频经颅交流电刺激(AM-tACS)是一种新型的电刺激方法,由于与经典电刺激方法相比,其刺激伪迹更容易去除,因此可以在刺激过程中记录电生理信号。为了评估 AM-tACS 的神经调节潜力,我们测试了其诱导光幻视的能力,将其作为刺激效果的指标。AM-tACS 通过两个电极设置进行施加,分别贴在 FpZ 和右眼下方。AM-tACS 波形由不同的载波(50 Hz、200 Hz、1000 Hz)和调制频率(8 Hz、16 Hz、28 Hz)组成,最大刺激强度为 2 mA 峰峰值。相同频率的 TACS 条件用作光幻视诱导的基准。使用 50 Hz 载波频率的 AM-tACS 条件能够诱导光幻视,但调制频率之间的光幻视阈值没有差异。使用 200 Hz 或 1000 Hz 载波频率的 AM-tACS 条件不能诱导光幻视。TACS 条件诱导的光幻视与之前的研究一致。AM-tACS 条件的刺激效果不依赖于幅度调制,而仅依赖于载波频率。一种可能的解释是,AM-tACS 需要更高的刺激强度,其幅度调制才能产生神经调节作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ebe/8593032/dbfb66c084f1/41598_2021_1482_Fig1_HTML.jpg

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