Liu Dan, Li Lin, An Lina, Cheng Guirong, Chen Cong, Zou Mingjun, Zhang Bo, Gan Xuguang, Xu Lang, Ou Yangming, Wu Qingming, Wang Ru, Zeng Yan
Brain Science and Advanced Technology Institute, Wuhan University of Science and Technology, Wuhan, Hubei, China.
Xiangyang Center for Disease Control and Prevention, Xiangyang, Hubei, China.
Gen Psychiatr. 2021 Oct 27;34(5):e100564. doi: 10.1136/gpsych-2021-100564. eCollection 2021.
Substantial variations in the prevalence of mild cognitive impairment (MCI) and its subtypes have been reported, although mostly in geographically defined developed countries and regions. Less is known about MCI and its subtypes in rural areas of less developed central China.
The study aimed to compare the prevalence of MCI and its subtypes in residents aged 65 years or older in urban and rural areas of Hubei Province, China.
Participants aged 65 years or older were recruited between 2018 and 2019. Inperson structured interviews and clinical and neuropsychological assessments were performed at city health community centres and township hospitals.
Among 2644 participants without dementia, 735 had MCI, resulting in a prevalence of 27.8% for total MCI, 20.9% for amnestic MCI (aMCI) and 6.9% for non-amnestic MCI (naMCI). The prevalence of MCI in urban and rural areas was 20.2% and 44.1%, respectively. After adjusting for demographic factors, the prevalence of total MCI, aMCI and naMCI differed significantly between rural and urban areas (adjusted odds ratio (OR) 2.10, 1.44 and 3.76, respectively). Subgroup analysis revealed an association between rural socioeconomic and lifestyle disadvantage and MCI and its subtypes.
Our findings suggest that the prevalence of MCI among urban residents in central China is consistent with that in other metropolis areas, such as Shanghai, but the prevalence in rural areas is twice that in urban areas. Prospective studies and dementia prevention in China should focus on rural areas.
尽管轻度认知障碍（MCI）及其亚型的患病率存在显著差异，但大多是在地理上明确的发达国家和地区报道的。关于中国中部欠发达农村地区的MCI及其亚型，人们了解较少。
本研究旨在比较中国湖北省城乡65岁及以上居民中MCI及其亚型的患病率。
招募2018年至2019年间65岁及以上的参与者。在城市健康社区中心和乡镇医院进行面对面的结构化访谈以及临床和神经心理学评估。
在2644名无痴呆的参与者中，735人患有MCI，总MCI患病率为27.8%，遗忘型MCI（aMCI）患病率为20.9%，非遗忘型MCI（naMCI）患病率为6.9%。城市和农村地区的MCI患病率分别为20.2%和44.1%。在调整人口统计学因素后，农村和城市地区的总MCI、aMCI和naMCI患病率存在显著差异（调整后的优势比（OR）分别为2.10、1.44和3.76）。亚组分析显示，农村社会经济和生活方式劣势与MCI及其亚型之间存在关联。
我们的研究结果表明，中国中部城市居民中MCI的患病率与上海等其他大都市地区一致，但农村地区的患病率是城市地区的两倍。中国的前瞻性研究和痴呆预防应关注农村地区。
