Department of Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P. R. China.
Department of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, P. R. China.
Alzheimers Dement. 2023 Jan;19(1):56-66. doi: 10.1002/alz.12629. Epub 2022 Mar 9.
Epidemiological studies of mild cognitive impairment (MCI) and subtypes of MCI have rarely focused on rural residents in China.
This population-based study included 5068 participants (age ≥60 years) who were living in rural communities. We defined MCI, amnestic MCI (aMCI), and non-amnestic MCI (naMCI) following the Petersen's criteria that integrated neuropsychological assessments with in-person clinical evaluations.
The overall prevalence of MCI, aMCI, and naMCI was 26.48%, 22.30%, and 4.18%, respectively. The prevalence of MCI increased with age. The adjusted odds ratio (OR) of MCI was 0.71 (95% confidence interval [CI] 0.61 to 0.82) for primary school (vs. illiteracy), 0.30 (0.24 to 0.39) for middle school or above, 1.35 (1.09 to 1.67) for being farmers, 0.65 (0.54 to 0.78) for alcohol consumption, 1.43 (1.20 to 1.70) for stroke history, and 1.14 (0.95 to 1.36) for any apolipoprotein E (APOE) ε4 allele (vs ε3/ε3).
MCI affects over one-fourth of rural older adults in China. Overall MCI was associated with demographic factors, non-alcohol consumption, and stroke, but not with APOE genotype and cardiometabolic factors.
轻度认知障碍（MCI）和 MCI 亚型的流行病学研究很少关注中国的农村居民。
本项基于人群的研究纳入了 5068 名（年龄≥60 岁）居住在农村社区的参与者。我们根据 Petersen 标准，将神经心理学评估与面对面临床评估相结合，定义了 MCI、遗忘型 MCI（aMCI）和非遗忘型 MCI（naMCI）。
MCI、aMCI 和 naMCI 的总患病率分别为 26.48%、22.30%和 4.18%。MCI 的患病率随年龄增长而增加。调整后的 MCI 患病比值比（OR）为：小学文化程度（vs. 文盲）为 0.71（95%置信区间 [CI] 0.61 至 0.82），中学或以上文化程度为 0.30（0.24 至 0.39），农民为 1.35（1.09 至 1.67），饮酒为 0.65（0.54 至 0.78），脑卒中史为 1.43（1.20 至 1.70），载脂蛋白 E（APOE）ε4 等位基因（vs. ε3/ε3）任何一个为 1.14（0.95 至 1.36）。
MCI 影响中国四分之一以上的农村老年人。总体而言，MCI 与人口统计学因素、非饮酒和脑卒中有关，但与 APOE 基因型和心血管代谢因素无关。
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