Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, 430022, China.
Small. 2022 Jan;18(1):e2104229. doi: 10.1002/smll.202104229. Epub 2021 Nov 17.
The treatment of diabetic wounds remains a major challenge in clinical practice, with chronic wounds characterized by multiple drug-resistant bacterial infections, angiopathy, and oxidative damage to the microenvironment. Herein, a novel in situ injectable HA@MnO /FGF-2/Exos hydrogel is introduced for improving diabetic wound healing. Through a simple local injection, this hydrogel is able to form a protective barrier covering the wound, providing rapid hemostasis and long-term antibacterial protection. The MnO /ε-PL nanosheet is able to catalyze the excess H O produced in the wound, converting it to O , thus not only eliminating the harmful effects of H O but also providing O for wound healing. Moreover, the release of M2-derived Exosomes (M2 Exos) and FGF-2 growth factor stimulates angiogenesis and epithelization, respectively. These in vivo and in vitro results demonstrate accelerated healing of diabetic wounds with the use of the HA@MnO /FGF-2/Exos hydrogel, presenting a viable strategy for chronic diabetic wound repair.
治疗糖尿病性创面仍然是临床实践中的一个主要挑战，慢性创面的特征是多种耐药菌感染、血管病变和微环境的氧化损伤。在此，介绍了一种新型的原位可注射 HA@MnO/FGF-2/Exos 水凝胶，用于改善糖尿病性创面愈合。通过简单的局部注射，该水凝胶能够形成覆盖创面的保护屏障，实现快速止血和长期的抗菌保护。MnO/ε-PL 纳米片能够催化创面中产生的多余 H O，将其转化为 O ，从而不仅消除了 H O 的有害影响，还为创面愈合提供了 O 。此外，M2 来源的外泌体（M2 Exos）和 FGF-2 生长因子的释放分别刺激血管生成和上皮化。这些体内和体外的结果表明，使用 HA@MnO/FGF-2/Exos 水凝胶可以加速糖尿病性创面的愈合，为慢性糖尿病性创面修复提供了一种可行的策略。
