Li Zhizhen, Yue Qingmei, Chen Yunjin, Zhang Yifan, Wan Yamin
Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
Int J Gen Med. 2022 Oct 29;15:7977-7984. doi: 10.2147/IJGM.S383783. eCollection 2022.
To characterize the pancreatic fat deposition (PFD) in patients with type 2 diabetes mellitus (T2DM) by quantitative computed tomography (QCT) and investigate the relationship between PFD and clinical metabolic parameters and islet function.
A total of 150 patients with T2DM and 93 age-matched healthy subjects underwent QCT to quantify PFD were included. PFD and various biochemical parameters were correlated by statistical methods and multiple stepwise linear regression modeling.
PFD measured by QCT in the T2DM group was statistically higher than that in the healthy control group, and the pancreatic CT value was statistically lower than that in the control group. The QCT measured PFD was negatively correlated with the pancreatic CT values (P < 0.001), and positively correlated with triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), visceral fat area (VAT) and insulin resistance index (HOMA-IR) (P < 0.05) in the T2DM patients. Multiple stepwise linear regression analysis identified PFD as the dependent variable factor for T2DM.
This study suggests QCT as a reliable technique in measuring PFD in T2DM. High PFD is positively correlated with the degree of insulin resistance and may play an important role in islet cell dysfunction in T2DM.
通过定量计算机断层扫描（QCT）对2型糖尿病（T2DM）患者的胰腺脂肪沉积（PFD）进行特征分析，并探讨PFD与临床代谢参数及胰岛功能之间的关系。
纳入总共150例T2DM患者和93例年龄匹配的健康受试者，他们均接受了QCT以量化PFD。通过统计方法和多元逐步线性回归模型对PFD与各种生化参数进行相关性分析。
T2DM组通过QCT测量的PFD在统计学上高于健康对照组，胰腺CT值在统计学上低于对照组。在T2DM患者中，QCT测量的PFD与胰腺CT值呈负相关（P < 0.001），与甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、内脏脂肪面积（VAT）和胰岛素抵抗指数（HOMA-IR）呈正相关（P < 0.05）。多元逐步线性回归分析确定PFD为T2DM的因变量因素。
本研究表明QCT是测量T2DM患者PFD的可靠技术。高PFD与胰岛素抵抗程度呈正相关，可能在T2DM患者的胰岛细胞功能障碍中起重要作用。
