Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Sleep Med. 2021 Dec;88:267-273. doi: 10.1016/j.sleep.2021.10.031. Epub 2021 Nov 8.
Currently, there is no consensus on the effect of sleep deprivation on male serum testosterone. This systematic review and meta-analysis aimed to determine the association between partial/total sleep deprivation and male serum testosterone level.
The literature related to sleep deprivation and male serum testosterone in the PubMed, Embase, and Cochrane Library databases were searched from their inception to July 15, 2021. Data were pooled using the Stata 15 software. The results were presented as standard mean differences (SMDs) with their 95% confidence intervals (CIs).
Eighteen studies involving 252 men were included in the systematic review and meta-analysis. The findings revealed that short-term partial sleep deprivation had no significant effect on male serum testosterone (SMD = -0.22; 95% CI: -0.5, 0.06; P = 0.13), while total sleep deprivation reduced the male testosterone levels (SMD = -0.64; 95% CI: -0.87, -0.42; P < 0.001). According to the intervention duration of total sleep deprivation, subgroup analysis was conducted by a fixed-effects model. The results revealed that the serum testosterone was significantly decreased after 24 h total sleep deprivation (SMD = - 0.67; 95% CI = - 0.93, -0.42, P < 0.001), as well as 40-48 h total sleep deprivation (SMD = - 0.74; 95% CI = - 1.22, -0.26, P = 0.002).
This meta-analysis revealed that total sleep deprivation (more than or equal to 24 h) reduces the male testosterone levels, while short-term partial sleep deprivation has no significant effect on male serum testosterone. Sleep duration plays a pivotal role in maintaining male serum testosterone levels.
目前，关于睡眠剥夺对男性血清睾酮的影响尚无共识。本系统评价和荟萃分析旨在确定部分/完全睡眠剥夺与男性血清睾酮水平之间的关联。
从建库至 2021 年 7 月 15 日，检索 PubMed、Embase 和 Cochrane Library 数据库中与睡眠剥夺和男性血清睾酮相关的文献。使用 Stata 15 软件汇总数据。结果以标准均数差（SMD）及其 95%置信区间（CI）表示。
系统评价和荟萃分析纳入了 18 项研究，共涉及 252 名男性。研究结果表明，短期部分睡眠剥夺对男性血清睾酮无显著影响（SMD=-0.22；95%CI：-0.5，0.06；P=0.13），而完全睡眠剥夺则降低了男性的睾酮水平（SMD=-0.64；95%CI：-0.87，-0.42；P<0.001）。根据完全睡眠剥夺的干预持续时间，采用固定效应模型进行亚组分析。结果显示，24 h 完全睡眠剥夺后（SMD=-0.67；95%CI：-0.93，-0.42；P<0.001）和 40-48 h 完全睡眠剥夺后（SMD=-0.74；95%CI：-1.22，-0.26；P=0.002），血清睾酮水平显著降低。
本荟萃分析显示，完全睡眠剥夺（≥24 h）会降低男性的睾酮水平，而短期部分睡眠剥夺对男性血清睾酮无显著影响。睡眠时长在维持男性血清睾酮水平方面发挥着关键作用。
