Armon-Omer Ayelet, Amir Eti, Neuman Hadar, Khateeb Saleh, Mizrachi Itai, Shalan Monia, Tamir Snait, Yatzkar Uri
Research Laboratory, Ziv Medical Center, Zefat, Israel.
Department of Nutrition, Ziv Medical Center, Zefat, Israel.
Front Psychiatry. 2021 Nov 5;12:740169. doi: 10.3389/fpsyt.2021.740169. eCollection 2021.
Attention deficit hyperactivity disorder (ADHD) is the most common developmental disorder in children. Studies suggest an association between fatty acids composition and ADHD pathogenesis. We aimed to investigate whether children diagnosed with ADHD present unique fatty acid profiles in red blood cells (RBC), as compared to children without ADHD. We examined 60 children aged 6-14 years, out of which 32 were diagnosed with ADHD, and 28 were not. Blood was collected from all children to quantify an array of 26 fatty acids from RBC membranes. Fatty acid methyl esters were generated by acid transesterification and analyzed by gas chromatography. We found that children with ADHD presented unique fatty acid profiles on RBC membranes with significantly higher levels of most of the trans-fatty acids (Total trans-fatty acids 0.64 ± 0.21 vs. 0.49 ± 0.18 = 0.003) and lower levels of docosahexaenoic acid (DHA), as compared to controls (4.06 ± 0.79 vs. 4.68 ± 1.37 = 0.040). Additionally, total trans-fatty acids were higher in children with extremely severe clinical ADHD condition score, as compared to milder ADHD scores and to control children (0.72 ± 0.18, 0.64 ± 0.20, 0.61 ± 0.22, 0.49 ± 0.18, = 0.010, accordingly). Children with ADHD have higher levels of trans-fatty acids in RBCs, compared to children without ADHD. This study points to a possible link between trans-fatty acids and ADHD. Understanding these findings and the clinical meaning will potentially contribute to a more targeted dietary intervention.
注意缺陷多动障碍（ADHD）是儿童中最常见的发育障碍。研究表明脂肪酸组成与ADHD发病机制之间存在关联。我们旨在调查与未患ADHD的儿童相比，被诊断为ADHD的儿童红细胞（RBC）中是否呈现独特的脂肪酸谱。我们检查了60名6至14岁的儿童，其中32名被诊断为ADHD，28名未患ADHD。从所有儿童采集血液，以定量红细胞膜中的一系列26种脂肪酸。通过酸酯交换反应生成脂肪酸甲酯，并通过气相色谱法进行分析。我们发现，与对照组相比，患有ADHD的儿童红细胞膜上呈现独特的脂肪酸谱，大多数反式脂肪酸水平显著更高（总反式脂肪酸0.64±0.21对0.49±0.18 = 0.003），而二十二碳六烯酸（DHA）水平较低（4.06±0.79对4.68±1.37 = 0.040）。此外，与轻度ADHD评分的儿童和对照组儿童相比，临床ADHD病情极为严重的儿童总反式脂肪酸含量更高（分别为0.72±0.18、0.64±0.20、0.61±0.22、0.49±0.18，相应地P = 0.010）。与未患ADHD的儿童相比，患有ADHD的儿童红细胞中的反式脂肪酸水平更高。这项研究指出了反式脂肪酸与ADHD之间可能存在的联系。理解这些发现及其临床意义可能会有助于更有针对性的饮食干预。
