Chen Lianyu, Hamarash Ibrahim Ismael, Jafari Sajad, Rajagopal Karthikeyan, Hussain Iqtadar
School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, 213001 China.
Electrical Engineering Department, Salahaddin University-Erbil, Kirkuk Rd., Erbil, Kurdistan Iraq.
Eur Phys J Spec Top. 2022;231(5):1015-1021. doi: 10.1140/epjs/s11734-021-00322-7. Epub 2021 Nov 13.
Cell development from an undifferentiated stem cell to a differentiated one is essential in forming an organism. In this paper, various bifurcations of a stem cell during this process are studied using a model based on Furusawa and Kaneko's hypothesis. Furusawa and Kaneko's hypothesis tells that the gene expression of stem cells is chaotic. By developing to a differentiated cell, the gene expression in more order, which is the cause of losing pluripotency. In this model, the chaotic dynamics of gene expression in the stem cells become ordered during the developments. Various patterns and bifurcation points can be seen during development. The bifurcation points and their predictions during the process of cell development are studied in this paper. Some well-known critical slowing down indicators are used to show the variations of slowness during the cell's development and predict the bifurcation points. It is vital since the unexpected changes of the state can cause a disaster. All of the indicators have a proper trend by approaching the bifurcation points and faring away.
细胞从未分化的干细胞发育为分化细胞对于生物体的形成至关重要。在本文中，基于古泽和金子的假说建立模型，研究了干细胞在此过程中的各种分岔情况。古泽和金子的假说表明干细胞的基因表达是混沌的。通过发育成为分化细胞，基因表达变得更加有序，这是失去多能性的原因。在这个模型中，干细胞中基因表达的混沌动力学在发育过程中变得有序。在发育过程中可以看到各种模式和分岔点。本文研究了细胞发育过程中的分岔点及其预测。一些著名的临界慢化指标被用来显示细胞发育过程中慢化的变化并预测分岔点。这至关重要，因为状态的意外变化可能导致灾难。所有指标在接近和远离分岔点时都有适当的趋势。
