Westwood S A, Seaman P J, O'Brien C, Thorogood L J
Central Research Establishment, Home Office Forensic Science Service, Reading, Berkshire, U.K.
Forensic Sci Int. 1987 Oct-Nov;35(2-3):197-207. doi: 10.1016/0379-0738(87)90056-9.
The phenotypic frequencies of group-specific component (Gc) and alpha-2-HS-glycoprotein (A2HS) were determined in White European, Asian and Afro-Caribbean populations. Typical allele frequencies were observed for Gc, with Gc 1S being the major allele for the first two groups and Gc 1F being the major allele for Afro-Caribbeans. For all groups the dominant A2HS allele was A2HS 1, although Asians had a significantly higher proportion of this allele than the White Europeans. Gc and A2HS either singly or in combination with other blood grouping systems provide good discriminating potential. The A2HS 10 allele was detected with a very low frequency in the White European group (A2HS 10 = 0.0013) and was not detected in the Asian group, while the Afro-Caribbean group had a relatively high frequency of this allele (A2HS 10 = 0.0966). The different distribution of the Gc 1F and A2HS 10 alleles in White Europeans and Asians compared with Afro-Caribbeans, can be used to determine the likelihood of blood coming from an Afro-Caribbean.
在白种欧洲人、亚洲人和非洲加勒比人群体中测定了群体特异性成分（Gc）和α-2-HS-糖蛋白（A2HS）的表型频率。观察到Gc具有典型的等位基因频率，在前两组中Gc 1S是主要等位基因，而在非洲加勒比人群体中Gc 1F是主要等位基因。对于所有群体，占主导地位的A2HS等位基因是A2HS 1，尽管亚洲人拥有该等位基因的比例明显高于白种欧洲人。Gc和A2HS单独或与其他血型系统结合都具有良好的鉴别潜力。在白种欧洲人群体中检测到A2HS 10等位基因的频率非常低（A2HS 10 = 0.0013），在亚洲人群体中未检测到，而非洲加勒比人群体中该等位基因的频率相对较高（A2HS 10 = 0.0966）。与非洲加勒比人群体相比，白种欧洲人和亚洲人中Gc 1F和A2HS 10等位基因的不同分布可用于确定血液来自非洲加勒比人的可能性。
