Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA.
Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.
Head Face Med. 2021 Nov 22;17(1):48. doi: 10.1186/s13005-021-00298-8.
Oral and oropharyngeal squamous cell carcinoma (SCC) is the 10th most common cancer in the United States (8th in males, 13th in females), with an estimated 54,010 new cases expected in 2021, and is primarily associated with smoked tobacco, heavy alcohol consumption, areca nut use and persistent high-risk human papillomavirus (HPV). Family history of cancer (FHC) and family history of head and neck cancer (FHHNC) have been reported to play an important role in the development of OSCC. We aimed to investigate the role of FHC, FHHNC and personal history of cancer in first/second degree-relatives as co-risk factors for oral cancer.
This was a retrospective study of patients diagnosed with OSCC at the Division of Oral Medicine and Dentistry at Brigham and Women's Hospital and at the Division of Head and Neck Oncology at Dana Farber Cancer Institute. Conditional logistic regressions were performed to examine whether OSCC was associated with FHC and FHHNC of FDRs and SDRs, personal history of cancer and secondary risk factors.
Overall, we did not find an association between FHC, FHHNC and OSCC risk, whereas patients with a cancer history in one of their siblings were 1.6-times more likely to present with an OSCC. When secondary risk factors were considered, patients with a history of oral leukoplakia and dysplasia had a 16-times higher risk of having an OSCC.
Our study confirmed that a previous history of oral leukoplakia or dysplasia was an independent risk factor for OSCC. A positive family history of cancer in one or more siblings may be an additional risk factor for OSCC.
口腔和口咽鳞状细胞癌（SCC）是美国第 10 常见的癌症（男性第 8，女性第 13），预计 2021 年将有 54,010 例新发病例，主要与吸烟、大量饮酒、食用槟榔和持续性高危型人乳头瘤病毒（HPV）有关。癌症家族史（FHC）和头颈部癌症家族史（FHHNC）已被报道在口腔鳞状细胞癌（OSCC）的发展中发挥重要作用。我们旨在研究 FHC、FHHNC 和一级/二级亲属的个人癌症史作为口腔癌的共同危险因素的作用。
这是一项回顾性研究，研究对象为在布莱根妇女医院口腔医学和牙科系以及达纳-法伯癌症研究所头颈肿瘤学系诊断为 OSCC 的患者。采用条件逻辑回归来检查 FDR 和 SDR 的 FHC 和 FHHNC、个人癌症史和二级危险因素是否与 OSCC 相关。
总体而言，我们没有发现 FHC、FHHNC 与 OSCC 风险之间存在关联，而在其兄弟姐妹中有癌症史的患者患 OSCC 的可能性增加了 1.6 倍。当考虑二级危险因素时，有口腔白斑病和发育不良病史的患者患 OSCC 的风险增加了 16 倍。
我们的研究证实，先前的口腔白斑病或发育不良病史是 OSCC 的独立危险因素。一个或多个兄弟姐妹有阳性癌症家族史可能是 OSCC 的另一个危险因素。
