Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas 77204, USA.
Food Funct. 2021 Dec 13;12(24):12550-12564. doi: 10.1039/d1fo02655k.
The gut microbiome is known to be involved in depression development. Thus, phytochemicals changing gut microbiota may alleviate depression-like behaviors. Coniferyl ferulate (CF) is a long studied natural product and known to alleviate psychiatric disorders. However, its mechanism of action remains unclear. In this experimental study, oral administration of 50 mg kg CF once daily attenuated weight loss and depression-like and anxiety-like behaviors induced by chronic unpredicted mild stress (CUMS) in mice. Four weeks of CF administration significantly ameliorated colonic inflammation, lowered the levels of IL-6, IL-1β, and TNF-α, and restructured the gut microbiome, and microbial metabolism. Intestinal microbiota can impact the development and function of the brain the microbiota-gut-brain axis. Therefore, oral administration of CF is a promising nutritional strategy to treat CUMS-induced depression the regulation of microbiota and microbial metabolism.
肠道微生物群与抑郁症的发展有关。因此，改变肠道微生物群的植物化学物质可能会缓解类似抑郁的行为。松柏醇阿魏酸酯（CF）是一种经过长期研究的天然产物，已知可缓解精神疾病。然而，其作用机制尚不清楚。在这项实验研究中，每日口服 50mg/kg CF 可减轻慢性不可预测轻度应激（CUMS）诱导的小鼠体重减轻和类似抑郁和焦虑的行为。四周的 CF 给药可显著改善结肠炎症，降低 IL-6、IL-1β 和 TNF-α 的水平，并重塑肠道微生物群和微生物代谢。肠道微生物群会影响大脑的发育和功能——微生物群-肠道-大脑轴。因此，口服 CF 是一种有前途的营养策略，可用于治疗 CUMS 诱导的抑郁——调节微生物群和微生物代谢。
