Ketterl R, Beckurts T, Stübinger B, Claudi B
Department of Surgery, Technical University Munich, West Germany.
J Antimicrob Chemother. 1988 Sep;22 Suppl C:159-66. doi: 10.1093/jac/22.supplement_c.159.
In two open prospective studies, the efficacy and tolerance of ofloxacin in the prevention of infection in patients with open fractures (n = 58) and in the treatment of chronic post-traumatic osteomyelitis (n = 115) were examined. In the study with open fractures, bone and/or soft tissue infection occurred in only four cases (6.5%). During an observation period of at least 12 months, post-traumatic osteomyelitis was seen in two patients with III degree open fractures (9%), while in the groups with I degree and II degree open fractures no bone infection could be found. Therefore, the rate of post-traumatic osteomyelitis related to all patients was 3.3%. In the second study with 115 patients suffering from chronic post-traumatic osteomyelitis 141 different Gram-positive and Gram-negative pathogens were isolated. 73% were Gram-positive cocci with Staphylococcus aureus in more than 50% of the cases. An elimination rate of more than 90% was found in the Gram-positive and Gram-negative bacteria, leading to a clinical cure in 85% and a recurrence of infection in 5% of the cases. The tolerability of ofloxacin was excellent. No drug-related allergic reactions were observed. Diarrhoea and headache occurred in less than 2% of patients. With adequate surgical treatment, ofloxacin proved to be a useful antimicrobial agent in the prevention and therapy of bone infection.
在两项开放性前瞻性研究中，对氧氟沙星在开放性骨折患者（n = 58）预防感染以及慢性创伤后骨髓炎患者（n = 115）治疗中的疗效和耐受性进行了研究。在开放性骨折研究中，仅4例（6.5%）发生了骨和/或软组织感染。在至少12个月的观察期内，两名Ⅲ度开放性骨折患者（9%）出现了创伤后骨髓炎，而在Ⅰ度和Ⅱ度开放性骨折组中未发现骨感染。因此，所有患者的创伤后骨髓炎发生率为3.3%。在第二项针对115例慢性创伤后骨髓炎患者的研究中，分离出141种不同的革兰氏阳性和革兰氏阴性病原体。73%为革兰氏阳性球菌，其中超过50%的病例为金黄色葡萄球菌。革兰氏阳性和革兰氏阴性细菌的清除率均超过90%，85%的病例实现临床治愈，5%的病例感染复发。氧氟沙星的耐受性良好。未观察到与药物相关的过敏反应。腹泻和头痛的发生率低于2%。在进行充分的手术治疗后，氧氟沙星被证明是预防和治疗骨感染的一种有效抗菌药物。
