Staib A H, Stille W, Dietlein G, Shah P M, Harder S, Mieke S, Beer C
Abteilung Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt.
Drugs. 1987;34 Suppl 1:170-4. doi: 10.2165/00003495-198700341-00035.
The effects of multiple doses of ofloxacin 200 mg, ciprofloxacin 250 mg or enoxacin 400 mg (all twice daily) on the pharmacokinetic properties of single doses of caffeine (220 to 230 mg) were investigated in 12 healthy volunteers. Intraindividual comparisons showed that ciprofloxacin and enoxacin significantly inhibited the elimination of caffeine. Ofloxacin, however, did not affect any of the measured pharmacokinetic properties of caffeine. Thus, caffeine should be avoided in patients with liver disorders, cardiac arrhythmias, latent epilepsy or in intensive care while undergoing treatment with enoxacin or ciprofloxacin.
在12名健康志愿者中研究了多次服用200毫克氧氟沙星、250毫克环丙沙星或400毫克依诺沙星（均每日两次）对单剂量咖啡因（220至230毫克）药代动力学特性的影响。个体内比较显示，环丙沙星和依诺沙星显著抑制咖啡因的消除。然而，氧氟沙星对所测量的咖啡因任何药代动力学特性均无影响。因此，在患有肝脏疾病、心律失常、潜在癫痫的患者或在接受依诺沙星或环丙沙星治疗时处于重症监护的患者中应避免使用咖啡因。
