美国德克萨斯州休斯顿市儿科人群中A组流行性猩红热菌株的鉴定。

Identification of epidemic scarlet fever group A strains in the paediatric population of Houston, TX, USA.

作者信息

Cubria M Belen, Delgado Jose, Shah Brittany J, Sanson Misu A, Flores Anthony R

机构信息

Division of Infectious Diseases, Department of Pediatrics, McGovern Medical School at the University of Texas Health Sciences Center at Houston, Houston, Texas, USA.

Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School at the University of Texas Health Sciences Center at Houston, Houston, Texas, USA.

出版信息

Access Microbiol. 2021 Oct 26;3(10):000274. doi: 10.1099/acmi.0.000274. eCollection 2021.

DOI:10.1099/acmi.0.000274

PMID:34816093

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8604173/

Abstract

Scarlet fever (SF) has recently been associated with group A streptococcal (GAS) strains possessing multidrug resistance and specific streptococcal exotoxins. We screened a local surveillance collection of GAS strains in Houston, TX, USA for antimicrobial resistance and identified a single isolate matching the antimicrobial resistance pattern previously reported for SF clones. Using whole-genome sequencing and combining genome sequence data derived from national surveillance databases, we identified additional GAS clones similar to those associated with prior SF outbreaks, emphasizing the need for continued surveillance for epidemic emergence in the USA.

摘要

猩红热（SF）最近与具有多重耐药性和特定链球菌外毒素的A组链球菌（GAS）菌株有关。我们在美国得克萨斯州休斯顿对当地监测收集的GAS菌株进行了抗菌药物耐药性筛查，发现了一株与先前报道的SF克隆株抗菌药物耐药模式相匹配的分离株。通过全基因组测序并结合来自国家监测数据库的基因组序列数据，我们鉴定出了其他与先前SF疫情相关的GAS克隆株，强调了在美国持续监测疫情出现情况的必要性。