Panda Sujogya Kumar, Luyten Walter
Department of Biology, KU Leuven, 3000 Leuven, Belgium; Center of Environment Climate Change and Public Health, RUSA 2.0, Utkal University, Vani Vihar, Bhubaneswar 751004, Odisha, India.
Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Drug Discov Today. 2022 Feb;27(2):636-651. doi: 10.1016/j.drudis.2021.11.017. Epub 2021 Nov 22.
Mushrooms are valued by humans worldwide as food, but also for their medicinal properties. Over 130 medicinal effects of mushrooms have been reported, including anti-diabetic, antioxidant, antimicrobial, anticancer, prebiotic, immunomodulating, anti-inflammatory and cardiovascular benefits. Several mushrooms have been tested in phase I, II, or III clinical trials for various diseases, including cancers, as well as to modulate immunity. Here, we review clinical studies on medicinal mushrooms or preparations (but not pure compounds) derived thereof. Overall, few phase III trials have been performed, and in many cases, these trials included a relatively small number of patients. Therefore, despite the promising published clinical data, especially on immune modulation, more work is required to clarify the therapeutic value of mushrooms.
蘑菇在全球范围内都受到人类重视，既因其可作为食物，也因其药用特性。已报道蘑菇具有超过130种药用功效，包括抗糖尿病、抗氧化、抗菌、抗癌、益生元、免疫调节、抗炎和心血管方面的益处。几种蘑菇已针对包括癌症在内的各种疾病以及调节免疫力进行了I期、II期或III期临床试验。在此，我们综述关于药用蘑菇或其衍生制剂（而非纯化合物）的临床研究。总体而言，III期试验开展较少，且在许多情况下，这些试验纳入的患者数量相对较少。因此，尽管已发表的临床数据很有前景，尤其是在免疫调节方面，但仍需要更多研究来阐明蘑菇的治疗价值。
