Department of General Surgery, The Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun, 130041, Jilin, China.
Stem Cell Res Ther. 2021 Nov 25;12(1):588. doi: 10.1186/s13287-021-02657-3.
Skin wound healing is a multi-stage process that depends on the coordination of multiple cells and mediators. Chronic or non-healing wounds resulting from the dysregulation of this process represent a challenge for the healthcare system. For skin wound management, there are various approaches to tissue recovery. For decades, stem cell therapy has made outstanding achievements in wound regeneration. Three major types of stem cells, including embryonic stem cells, adult stem cells, and induced pluripotent stem cells, have been explored intensely. Mostly, mesenchymal stem cells are thought to be an extensive cell type for tissue repair. However, the limited cell efficacy and the underutilized therapeutic potential remain to be addressed. Exploring novel and advanced treatments to enhance stem cell efficacy is an urgent need. Diverse strategies are applied to maintain cell survival and increase cell functionality. In this study, we outline current approaches aiming to improve the beneficial outcomes of cell therapy to better grasp clinical cell transformation.
皮肤伤口愈合是一个多阶段的过程，依赖于多种细胞和介质的协调。由于该过程失调而导致的慢性或非愈合性伤口对医疗保健系统构成了挑战。对于皮肤伤口管理，有多种组织恢复方法。几十年来，干细胞疗法在伤口再生方面取得了杰出的成就。包括胚胎干细胞、成体干细胞和诱导多能干细胞在内的三大类干细胞都得到了深入研究。间充质干细胞被认为是一种广泛用于组织修复的细胞类型。然而，细胞功效有限和治疗潜力未被充分利用仍是亟待解决的问题。探索新的先进治疗方法来提高干细胞的功效是当务之急。目前应用了多种策略来维持细胞存活和提高细胞功能。在本研究中，我们概述了旨在提高细胞治疗有益效果的当前方法，以便更好地掌握临床细胞转化。
