过敏反应：数据缺口与研究需求。
Anaphylaxis: Data Gaps and Research Needs.
机构信息
Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, 3244 Burnet Avenue, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Hale BTM Building Room 5002N, 60 Fenwood Road, Boston, MA 02115, USA.
出版信息
Immunol Allergy Clin North Am. 2022 Feb;42(1):187-200. doi: 10.1016/j.iac.2021.10.002.
There are significant anaphylaxis data and knowledge gaps that result in suboptimal patient care and outcomes. To address these gaps there is need for collaborative, multidisciplinary research networks to strategically design practice changing research specific to the following anaphylaxis themes: Population Science, Basic and Translational Sciences, Acute Management, and Long-Term Management. Top priorities are to refine anaphylaxis diagnostic criteria, identify accurate diagnostic and predictive anaphylaxis biomarkers, standardize postanaphylaxis care (observation periods, hospitalization criteria), and determine immunotherapy best practices. Addressing these gaps will result in improved, optimal care and clinical outcomes for patients with or at risk of anaphylaxis.
存在严重的过敏反应数据和知识差距，导致患者的护理和结果不理想。为了弥补这些差距，需要协作的多学科研究网络，针对以下过敏反应主题战略性地设计改变实践的研究：人群科学、基础和转化科学、急性管理和长期管理。当务之急是完善过敏反应的诊断标准，确定准确的诊断和预测过敏反应的生物标志物，标准化过敏反应后的护理（观察期、住院标准），并确定免疫治疗的最佳实践。解决这些差距将改善过敏反应患者或有过敏反应风险患者的护理和临床结果。
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