The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, NR4 7UK, England, UK.
KWS SAAT SE & Co. KGaA, 37574, Einbeck, Germany.
Nat Commun. 2021 Nov 25;12(1):6915. doi: 10.1038/s41467-021-27288-3.
Crop losses caused by plant pathogens are a primary threat to stable food production. Stripe rust (Puccinia striiformis) is a fungal pathogen of cereal crops that causes significant, persistent yield loss. Stripe rust exhibits host species specificity, with lineages that have adapted to infect wheat and barley. While wheat stripe rust and barley stripe rust are commonly restricted to their corresponding hosts, the genes underlying this host specificity remain unknown. Here, we show that three resistance genes, Rps6, Rps7, and Rps8, contribute to immunity in barley to wheat stripe rust. Rps7 cosegregates with barley powdery mildew resistance at the Mla locus. Using transgenic complementation of different Mla alleles, we confirm allele-specific recognition of wheat stripe rust by Mla. Our results show that major resistance genes contribute to the host species specificity of wheat stripe rust on barley and that a shared genetic architecture underlies resistance to the adapted pathogen barley powdery mildew and non-adapted pathogen wheat stripe rust.
作物病害导致的减产是稳定粮食生产的主要威胁。条锈病（Puccinia striiformis）是一种真菌病原体，可导致谷类作物严重且持续的产量损失。条锈病表现出宿主物种特异性，有适应感染小麦和大麦的谱系。虽然小麦条锈病和大麦条锈病通常局限于其相应的宿主，但导致这种宿主特异性的基因仍然未知。在这里，我们表明三个抗性基因，Rps6、Rps7 和 Rps8，有助于大麦对小麦条锈病的免疫。Rps7 在 Mla 基因座与大麦白粉病抗性共分离。利用不同 Mla 等位基因的转基因互补，我们证实了 Mla 对小麦条锈病的等位基因特异性识别。我们的结果表明，主要抗性基因有助于小麦条锈病在大麦上的宿主种特异性，并且对适应病原体大麦白粉病和非适应病原体小麦条锈病的抗性具有共同的遗传结构。
