Lerond Clara, Hudry Julie, Zahar Sélima, Makwana Aidan, Schneider Nora
Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé SA, Vers-chez-les-Blanc, Lausanne, Switzerland.
Int J Clin Pediatr Dent. 2021 Jul-Aug;14(4):525-530. doi: 10.5005/jp-journals-10005-2002.
Irritability and discomfort are common symptoms during teething periods in infants and toddlers. Non-pharmacological remedies to relieve teething symptoms include teethers and food for chewing. However, the efficacy of such remedies for their soothing effect has been poorly investigated.
In this home-based pilot study, the soothing effect of a novel edible teether with a slowly dissolvable texture was investigated in 12 children aged 5 to 19 months old during primary dentition age. After parents observed their child getting irritable, the child received the edible teether for an exposure duration of 15 to 20 minutes. Parental ratings of children's mood states (crankiness, stress, happiness, and calmness) were collected using visual analog scales, and child cardiac measurements (heart rate and heart rate variability) were assessed using a wearable device. The soothing effect was quantified via mood ratings and physiological calming responses as a before-after comparison using Wilcoxon signed-rank tests.
Parents perceived their child as significantly calmer and happier, less stressed, and marginally less cranky after edible teether exposure than before. The child cardiac variables showed no significant changes; however, exposure to the teether induced a marginal increase in HR within normal ranges, potentially indicating a stimulation effect.
The pilot study provides the first insight on the soothing effect of a novel edible teether on parent-reported mood states in young children during primary dentition age. Further research is needed to understand the relative contribution of the different components of an edible teether to the observed effects, such as texture and exposure duration, and to demonstrate its efficacy against a control product.
Swiss registry of clinical trial: CER-VD 2019-02155.
Lerond C, Hudry J, Zahar S, Soothing Effect of an Edible Teether: A Pilot Study in Children during Primary Dentition Age. Int J Clin Pediatr Dent 2021;14(4):525-530.
烦躁和不适是婴幼儿出牙期的常见症状。缓解出牙症状的非药物疗法包括牙胶和可咀嚼食物。然而，此类疗法舒缓效果的有效性研究较少。
在这项基于家庭的试点研究中，对12名处于乳牙列期、年龄在5至19个月的儿童，研究了一种质地缓慢溶解的新型可食用牙胶的舒缓效果。在家长观察到孩子变得烦躁后，让孩子使用可食用牙胶15至20分钟。使用视觉模拟量表收集家长对孩子情绪状态（烦躁、压力、快乐和平静）的评分，并使用可穿戴设备评估孩子的心脏测量指标（心率和心率变异性）。通过情绪评分和生理平静反应，使用Wilcoxon符号秩检验进行前后比较，对舒缓效果进行量化。
与使用前相比，家长认为孩子在使用可食用牙胶后明显更平静、更快乐、压力更小，烦躁程度也略有降低。孩子的心脏变量没有显著变化；然而，接触牙胶会使心率在正常范围内略有增加，这可能表明有刺激作用。
该试点研究首次揭示了一种新型可食用牙胶对乳牙列期幼儿家长报告的情绪状态的舒缓效果。需要进一步研究以了解可食用牙胶不同成分（如质地和接触时间）对观察到的效果的相对贡献，并证明其相对于对照产品的疗效。
瑞士临床试验注册中心：CER-VD 2019-02155。
勒龙德C，于德里J，扎哈尔S，《可食用牙胶的舒缓效果：乳牙列期儿童的试点研究》。《国际临床儿科牙科学杂志》2021年；14(4):525 - 530。
