Tsuge Mitsuru, Ikeda Masanori, Matsumoto Naomi, Yorifuji Takashi, Tsukahara Hirokazu
Department of Pediatric Acute Diseases, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Department of Pediatrics, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Children (Basel). 2021 Nov 19;8(11):1067. doi: 10.3390/children8111067.
The incidence of allergic diseases is increasing, and research on their epidemiology, pathophysiology, and the prevention of onset is urgently needed. The onset of allergic disease begins in infancy with atopic dermatitis and food allergy and develops into allergic asthma and allergic rhinitis in childhood; the process is defined as "atopic march". Atopic march is caused by multiple immunological pathways, including allergen exposure, environmental pollutants, skin barrier dysfunction, type 2 inflammation, and oxidative stress, which promote the progression of atopic march. Using recent evidence, herein, we explain the involvement of allergic inflammatory conditions and oxidative stress in the process of atopic march, its epidemiology, and methods for prevention of onset.
过敏性疾病的发病率正在上升，迫切需要对其流行病学、病理生理学和发病预防进行研究。过敏性疾病始于婴儿期的特应性皮炎和食物过敏，并在儿童期发展为过敏性哮喘和过敏性鼻炎；这个过程被定义为“特应性进程”。特应性进程由多种免疫途径引起，包括过敏原暴露、环境污染物、皮肤屏障功能障碍、2型炎症和氧化应激，这些因素促进了特应性进程的发展。本文利用最新证据，解释了过敏性炎症状态和氧化应激在特应性进程中的作用、其流行病学以及发病预防方法。
