Prakash Vidhya, Krishnan Akshaya S, Ramesh Reshma, Bose Chinchu, Pillai Girinath G, Nair Bipin G, Pal Sanjay
School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690525, India.
Discovery Chemistry, Nyro Research India, Kochi 682021, India.
Foods. 2021 Oct 22;10(11):2548. doi: 10.3390/foods10112548.
Value-added phytochemicals from food by-products and waste materials have gained much interest and among them, dietary polyphenolic compounds with potential biological properties extend a promising sustainable approach. Oxyresveratrol (Oxy), a stilbenoid polyphenol, possesses great therapeutic potential, though its pharmacokinetic issues need attention. A good source of oxyresveratrol was found in underutilized coconut shells and the synbiotic applications of the compound in combination with a potential probiotic isolate ASBT-2 was investigated. The compound showed lower inhibitory effects on the strain with minimum inhibitory concentration (MIC) of 1000 µg/mL. Oxyresveratrol at sub-MIC concentrations (500 µg/mL and 250 µg/mL) enhanced the probiotic properties without exerting any inhibitory effects on the strain. The combination at sub- MIC concentration of the compound inhibited and in silico approaches were employed to elucidate the possible mode of action of oxy on the pathogen. Thus, the combination could target pathogens in the gut without exerting negative impacts on growth of beneficial strains. This approach could be a novel perspective to address the poor pharmacokinetic properties of the compound.
来自食品副产品和废料的增值植物化学物质备受关注，其中具有潜在生物学特性的膳食多酚化合物提供了一种有前景的可持续方法。氧化白藜芦醇（Oxy）是一种芪类多酚，具有巨大的治疗潜力，不过其药代动力学问题需要关注。在未充分利用的椰壳中发现了氧化白藜芦醇的良好来源，并研究了该化合物与潜在益生菌分离株ASBT-2的合生元应用。该化合物对该菌株的抑制作用较低，最低抑菌浓度（MIC）为1000 µg/mL。亚MIC浓度（500 µg/mL和250 µg/mL）的氧化白藜芦醇增强了益生菌特性，而对该菌株没有任何抑制作用。该化合物在亚MIC浓度下的组合抑制了……并采用计算机模拟方法阐明氧化白藜芦醇对病原体可能的作用方式。因此，该组合可以靶向肠道中的病原体，而不会对有益菌株的生长产生负面影响。这种方法可能是解决该化合物不良药代动力学特性的一个新视角。
