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CECT5716:机制与治疗新视角。

CECT5716: Mechanisms and Therapeutic Insights.

机构信息

CIBER-EHD, Center for Biomedical Research (CIBM), Department of Pharmacology, University of Granada, 18071 Granada, Spain.

Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18014 Granada, Spain.

出版信息

Nutrients. 2021 Mar 21;13(3):1016. doi: 10.3390/nu13031016.

Abstract

Probiotics microorganisms exert their health-associated activities through some of the following general actions: competitive exclusion, enhancement of intestinal barrier function, production of bacteriocins, improvement of altered microbiota, and modulation of the immune response. Among them, CECT5716 has become one of the most promising probiotics and it has been described to possess potential beneficial effects on inflammatory processes and immunological alterations. Different studies, preclinical and clinical trials, have evidenced its anti-inflammatory and immunomodulatory properties and elucidated the precise mechanisms of action involved in its beneficial effects. Therefore, the aim of this review is to provide an updated overview of the effect on host health, mechanisms, and future therapeutic approaches.

摘要

益生菌微生物通过以下几种一般作用发挥其与健康相关的活性

竞争性排斥、增强肠道屏障功能、产生细菌素、改善改变的微生物群,以及调节免疫反应。其中,CECT5716 已成为最有前途的益生菌之一,据描述,它对炎症过程和免疫改变具有潜在的有益作用。不同的研究,包括临床前和临床试验,已经证明了其抗炎和免疫调节特性,并阐明了其有益作用涉及的确切作用机制。因此,本综述的目的是提供对宿主健康、机制和未来治疗方法的最新概述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6580/8003974/7162f2389fd3/nutrients-13-01016-g001.jpg

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