Nrf2在骨骼肌对运动能力方面的作用。
The Role of Nrf2 in Skeletal Muscle on Exercise Capacity.
作者信息
Kitaoka Yu
机构信息
Department of Human Sciences, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Kanagawa, Japan.
出版信息
Antioxidants (Basel). 2021 Oct 27;10(11):1712. doi: 10.3390/antiox10111712.
Abstract
Nuclear factor erythroid 2-related factor 2 Nfe2l2 (Nrf2) is believed to play a crucial role in protecting cells against oxidative stress. In addition to its primary function of maintaining redox homeostasis, there is emerging evidence that Nrf2 is also involved in energy metabolism. In this review, we briefly discuss the role of Nrf2 in skeletal muscle metabolism from the perspective of exercise physiology. This article is part of a special issue "Mitochondrial Function, Reactive Oxygen/Nitrogen Species and Skeletal Muscle" edited by Håkan Westerblad and Takashi Yamada.
摘要
核因子红细胞2相关因子2（Nfe2l2，即Nrf2）被认为在保护细胞免受氧化应激方面发挥着关键作用。除了维持氧化还原稳态的主要功能外，越来越多的证据表明Nrf2也参与能量代谢。在这篇综述中，我们从运动生理学的角度简要讨论Nrf2在骨骼肌代谢中的作用。本文是由哈坎·韦斯特布拉德（Håkan Westerblad）和山田隆史（Takashi Yamada）编辑的特刊“线粒体功能、活性氧/氮物种与骨骼肌”的一部分。
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2
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J Physiol. 2020 Dec;598(23):5427-5451. doi: 10.1113/JP280176. Epub 2020 Sep 23.
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8
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