Nrf2在骨骼肌对运动能力方面的作用。
The Role of Nrf2 in Skeletal Muscle on Exercise Capacity.
作者信息
Kitaoka Yu
机构信息
Department of Human Sciences, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Kanagawa, Japan.
出版信息
Antioxidants (Basel). 2021 Oct 27;10(11):1712. doi: 10.3390/antiox10111712.
Abstract
Nuclear factor erythroid 2-related factor 2 Nfe2l2 (Nrf2) is believed to play a crucial role in protecting cells against oxidative stress. In addition to its primary function of maintaining redox homeostasis, there is emerging evidence that Nrf2 is also involved in energy metabolism. In this review, we briefly discuss the role of Nrf2 in skeletal muscle metabolism from the perspective of exercise physiology. This article is part of a special issue "Mitochondrial Function, Reactive Oxygen/Nitrogen Species and Skeletal Muscle" edited by Håkan Westerblad and Takashi Yamada.
摘要
核因子红细胞2相关因子2（Nfe2l2，即Nrf2）被认为在保护细胞免受氧化应激方面发挥着关键作用。除了维持氧化还原稳态的主要功能外，越来越多的证据表明Nrf2也参与能量代谢。在这篇综述中，我们从运动生理学的角度简要讨论Nrf2在骨骼肌代谢中的作用。本文是由哈坎·韦斯特布拉德（Håkan Westerblad）和山田隆史（Takashi Yamada）编辑的特刊“线粒体功能、活性氧/氮物种与骨骼肌”的一部分。
相似文献
1
The Role of Nrf2 in Skeletal Muscle on Exercise Capacity.
Antioxidants (Basel). 2021 Oct 27;10(11):1712. doi: 10.3390/antiox10111712.
2
Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice.
J Physiol. 2016 Sep 15;594(18):5195-207. doi: 10.1113/JP271957. Epub 2016 May 27.
3
Hypoxia preconditioning promotes endurance exercise capacity of mice by activating skeletal muscle Nrf2.
J Appl Physiol (1985). 2019 Nov 1;127(5):1267-1277. doi: 10.1152/japplphysiol.00347.2019. Epub 2019 Sep 5.
4
Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria.
Toxicol Appl Pharmacol. 2018 Nov 15;359:24-33. doi: 10.1016/j.taap.2018.09.014. Epub 2018 Sep 18.
5
Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles.
Sci Rep. 2017 Oct 10;7(1):12902. doi: 10.1038/s41598-017-12926-y.
6
Unlocking peak performance: The role of Nrf2 in enhancing exercise outcomes and training adaptation in humans.
Free Radic Biol Med. 2024 Nov 1;224:168-181. doi: 10.1016/j.freeradbiomed.2024.08.011. Epub 2024 Aug 14.
7
The role of Nrf2 in skeletal muscle contractile and mitochondrial function.
J Appl Physiol (1985). 2016 Sep 1;121(3):730-40. doi: 10.1152/japplphysiol.00042.2016. Epub 2016 Jul 28.
8
A systematic review of p53 regulation of oxidative stress in skeletal muscle.
Redox Rep. 2018 Dec;23(1):100-117. doi: 10.1080/13510002.2017.1416773. Epub 2018 Jan 3.
9
p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle.
FASEB J. 2019 Jul;33(7):8022-8032. doi: 10.1096/fj.201900133R. Epub 2019 Mar 26.
10
Cytoprotective Role of Nrf2 in Electrical Pulse Stimulated C2C12 Myotube.
PLoS One. 2015 Dec 14;10(12):e0144835. doi: 10.1371/journal.pone.0144835. eCollection 2015.
引用本文的文献
1
Muscle mTOR controls iron homeostasis and ferritinophagy via NRF2, HIFs and AKT/PKB signaling pathways.
Cell Mol Life Sci. 2025 Apr 28;82(1):178. doi: 10.1007/s00018-025-05695-9.
2
Combined Effects of Spirulina Liquid Extract and Endurance Training on Aerobic Performance and Muscle Metabolism Adaptation in Wistar Rats.
Nutrients. 2025 Jan 14;17(2):283. doi: 10.3390/nu17020283.
3
Does Vitamin B6 Act as an Exercise Mimetic in Skeletal Muscle?
Int J Mol Sci. 2024 Sep 15;25(18):9962. doi: 10.3390/ijms25189962.
4
Phycocyanin attenuates skeletal muscle damage and fatigue via modulation of Nrf2 and IRS-1/AKT/mTOR pathway in exercise-induced oxidative stress in rats.
PLoS One. 2024 Sep 10;19(9):e0310138. doi: 10.1371/journal.pone.0310138. eCollection 2024.
5
Aging-associated Aberrant Mitochondrial Redox Signaling, Physical Activity, and Sarcopenia.
Curr Aging Sci. 2025;18(2):120-131. doi: 10.2174/0118746098315667240606052523.
6
Polyphenol supplementation boosts aerobic endurance in athletes: systematic review.
Front Physiol. 2024 Apr 8;15:1369174. doi: 10.3389/fphys.2024.1369174. eCollection 2024.
7
Identification of mulberry leaf flavonoids and evaluating their protective effects on HO-induced oxidative damage in equine skeletal muscle satellite cells.
Front Mol Biosci. 2024 Apr 8;11:1353387. doi: 10.3389/fmolb.2024.1353387. eCollection 2024.
8
Nrf2 modulates the benefits of evening exercise in type 2 diabetes.
Sports Med Health Sci. 2023 Sep 9;5(4):251-258. doi: 10.1016/j.smhs.2023.09.001. eCollection 2023 Dec.
9
Long-term iron supplementation combined with vitamin B6 enhances maximal oxygen uptake and promotes skeletal muscle-specific mitochondrial biogenesis in rats.
Front Nutr. 2024 Jan 15;10:1335187. doi: 10.3389/fnut.2023.1335187. eCollection 2023.
10
The Molecular Mechanisms of Fuel Utilization during Exercise.
Biology (Basel). 2023 Nov 19;12(11):1450. doi: 10.3390/biology12111450.
本文引用的文献
1
High intensity muscle stimulation activates a systemic Nrf2-mediated redox stress response.
Free Radic Biol Med. 2021 Aug 20;172:82-89. doi: 10.1016/j.freeradbiomed.2021.05.039. Epub 2021 Jun 3.
2
Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice.
Redox Biol. 2021 Jul;43:101966. doi: 10.1016/j.redox.2021.101966. Epub 2021 Apr 5.
3
NQO1 protects obese mice through improvements in glucose and lipid metabolism.
NPJ Aging Mech Dis. 2020 Nov 19;6(1):13. doi: 10.1038/s41514-020-00051-6.
4
Functional, proteomic and bioinformatic analyses of Nrf2- and Keap1- null skeletal muscle.
J Physiol. 2020 Dec;598(23):5427-5451. doi: 10.1113/JP280176. Epub 2020 Sep 23.
5
Regulation of Nrf2/Keap1 signalling in human skeletal muscle during exercise to exhaustion in normoxia, severe acute hypoxia and post-exercise ischaemia: Influence of metabolite accumulation and oxygenation.
Redox Biol. 2020 Sep;36:101627. doi: 10.1016/j.redox.2020.101627. Epub 2020 Jun 30.
6
Loss of NRF2 leads to impaired mitochondrial function, decreased synaptic density and exacerbated age-related cognitive deficits.
Exp Gerontol. 2020 Mar;131:110767. doi: 10.1016/j.exger.2019.110767. Epub 2019 Dec 13.
7
The impact of acute and chronic exercise on Nrf2 expression in relation to markers of mitochondrial biogenesis in human skeletal muscle.
Eur J Appl Physiol. 2020 Jan;120(1):149-160. doi: 10.1007/s00421-019-04259-7. Epub 2019 Nov 9.
8
Hypoxia preconditioning promotes endurance exercise capacity of mice by activating skeletal muscle Nrf2.
J Appl Physiol (1985). 2019 Nov 1;127(5):1267-1277. doi: 10.1152/japplphysiol.00347.2019. Epub 2019 Sep 5.
9
p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle.
FASEB J. 2019 Jul;33(7):8022-8032. doi: 10.1096/fj.201900133R. Epub 2019 Mar 26.
10
Effects of Nrf2 deficiency on mitochondrial oxidative stress in aged skeletal muscle.
Physiol Rep. 2019 Feb;7(3):e13998. doi: 10.14814/phy2.13998.
Zotero 插件