Juncker Hannah G, Ruhé Eliza J M, Burchell George L, van den Akker Chris H P, Korosi Aniko, van Goudoever Johannes B, van Keulen Britt J
Amsterdam UMC, Emma Children's Hospital, Department of Pediatrics, Amsterdam Reproduction & Development Research Institute, 1105 AZ Amsterdam, The Netherlands.
Swammerdam Institute for Life Sciences-Center for Neuroscience, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.
Antioxidants (Basel). 2021 Oct 29;10(11):1737. doi: 10.3390/antiox10111737.
High rates of oxidative stress are common in preterm born infants and have short- and long-term consequences. The antioxidant properties of human milk limits the consequences of excessive oxidative damage. However, as the mother's own milk it is not always available, donor milk may be provided as the best alternative. Donor milk needs to be pasteurized before use to ensure safety. Although pasteurization is necessary for safety reasons, it may affect the activity and concentration of several biological factors, including antioxidants. This literature review describes the effect of different pasteurization methods on antioxidant properties of human milk and aims to provide evidence to guide donor milk banks in choosing the best pasteurization method from an antioxidant perspective. The current literature suggests that Holder pasteurization reduces the antioxidant properties of human milk. Alternative pasteurization methods seem promising as less reduction is observed in several studies.
早产婴儿中氧化应激发生率较高，且会产生短期和长期后果。母乳的抗氧化特性可限制过度氧化损伤的后果。然而，由于并非总能获得母亲自己的母乳，捐赠母乳可能是最佳替代选择。捐赠母乳在使用前需要进行巴氏杀菌以确保安全。尽管出于安全原因巴氏杀菌是必要的，但它可能会影响包括抗氧化剂在内的几种生物因子的活性和浓度。这篇文献综述描述了不同巴氏杀菌方法对母乳抗氧化特性的影响，旨在提供证据，从抗氧化角度指导母乳库选择最佳巴氏杀菌方法。当前文献表明，低温长时间巴氏杀菌会降低母乳的抗氧化特性。替代巴氏杀菌方法似乎很有前景，因为在多项研究中观察到其降低程度较小。
