Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Department of Gynecological Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Cells. 2021 Nov 8;10(11):3074. doi: 10.3390/cells10113074.
As the outermost barrier, skin plays an important role in protecting our bodies against outside invasion. Under stable conditions or during inflammation, leukocytes migration is essential for restoring homeostasis in the skin. Immune cells trafficking is orchestrated by chemokines; leukocytes express receptors that bind to chemokines and trigger migration. The homeostasis of the immune ecosystem is an extremely complicated dynamic process that requires the cooperation of innate and adaptive immune cells. Emerging studies have been shedding a light on the unique characteristics of skin-resident innate lymphoid cells (ILCs). In this review, we discuss how chemokines orchestrate skin ILCs trafficking and contribute to tissue homeostasis and how abnormal chemokine-chemokine receptor interactions contribute to and augment skin inflammation, as seen in conditions such as contact hypersensitivity, atopic dermatitis, and psoriasis.
皮肤作为人体的最外层屏障，对于抵御外界入侵起着重要作用。在稳定状态或炎症期间，白细胞的迁移对于恢复皮肤的内稳态至关重要。趋化因子协调免疫细胞的迁移；白细胞表达的受体与趋化因子结合并触发迁移。免疫生态系统的内稳态是一个极其复杂的动态过程，需要先天和适应性免疫细胞的合作。新出现的研究揭示了皮肤固有淋巴细胞（ILC）的独特特征。在这篇综述中，我们讨论了趋化因子如何协调皮肤 ILC 的迁移，以及如何促进组织内稳态，以及异常的趋化因子-趋化因子受体相互作用如何导致和加剧皮肤炎症，如接触性过敏、特应性皮炎和银屑病等疾病。
