Seedat R Y
Department of Otorhinolaryngology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Pediatric Health Med Ther. 2020 Feb 4;11:39-46. doi: 10.2147/PHMT.S200186. eCollection 2020.
Recurrent respiratory papillomatosis (RRP) is a condition caused by human papillomavirus (HPV), usually HPV types 6 and 11, which is characterized by recurrent papillomas of the respiratory tract, mainly the larynx. Patients usually present between the ages of 2 and 6 years. The initial presenting symptom is progressive dysphonia, followed by stridor and respiratory distress. Treatment consists of repeated microlaryngoscopic procedures to remove the papillomas as there is no cure. The poor availability and accessibility of appropriate healthcare services in developing countries are barriers to the early diagnosis and appropriate management of patients with juvenile-onset recurrent respiratory papillomatosis (JoRRP), requiring many patients to have a tracheostomy. The introduction of prophylactic vaccines that include HPV6 and HPV11 is necessary in order to reduce the incidence of JoRRP.
复发性呼吸道乳头状瘤病（RRP）是一种由人乳头瘤病毒（HPV）引起的疾病，通常为HPV 6型和11型，其特征是呼吸道反复出现乳头状瘤，主要发生在喉部。患者通常在2至6岁之间发病。最初的症状是进行性声音嘶哑，随后出现喘鸣和呼吸窘迫。由于无法治愈，治疗方法是反复进行显微喉镜手术以切除乳头状瘤。发展中国家适当的医疗服务可及性差，这是幼年型复发性呼吸道乳头状瘤病（JoRRP）患者早期诊断和适当管理的障碍，导致许多患者需要进行气管切开术。为了降低JoRRP的发病率，引入包含HPV6和HPV11的预防性疫苗是必要的。
