Vazquez-Munoz Roberto, Arellano-Jimenez M Josefina, Lopez-Ribot Jose L
The University of Texas at San Antonio, San Antonio, TX 78249 USA.
The University of Texas at Dallas, Richardson, TX 75080 USA.
BMC Biomed Eng. 2020 Oct 14;2:11. doi: 10.1186/s42490-020-00044-2. eCollection 2020.
Bismuth compounds are known for their activity against multiple microorganisms; yet, the antibiotic properties of bismuth nanoparticles (BiNPs) remain poorly explored. The objective of this work is to further the research of BiNPs for nanomedicine-related applications. Stable Polyvinylpyrrolidone (PVP)-coated BiNPs were produced by a chemical reduction process, in less than 30 min.
We produced stable, small, spheroid PVP-coated BiNPs with a crystalline organization. The PVP-BiNPs showed potent antibacterial activity against the pathogenic bacterium and antifungal activity against the opportunistic pathogenic yeast , both under planktonic and biofilm growing conditions.
Our results indicate that BiNPs represent promising antimicrobial nanomaterials, and this facile synthetic method may allow for further investigation of their activity against a variety of pathogenic microorganisms.
铋化合物因其对多种微生物的活性而闻名；然而，铋纳米颗粒（BiNPs）的抗菌特性仍未得到充分研究。这项工作的目的是进一步研究BiNPs在纳米医学相关应用中的作用。通过化学还原过程在不到30分钟内制备出了稳定的聚乙烯吡咯烷酮（PVP）包覆的BiNPs。
我们制备出了具有晶体结构的稳定、小尺寸、球形的PVP包覆的BiNPs。在浮游和生物膜生长条件下，PVP-BiNPs对病原菌显示出强大的抗菌活性，对机会致病性酵母显示出抗真菌活性。
我们的结果表明，BiNPs是有前景的抗菌纳米材料，这种简便的合成方法可能有助于进一步研究它们对多种致病微生物的活性。
