Sakurai Takuma, Horigome Ayako, Odamaki Toshitaka, Shimizu Takashi, Xiao Jin-Zhong
Next Generation Science Institute, Morinaga Milk Industry Co., Ltd., Zama 252-8583, Japan.
Microorganisms. 2021 Nov 21;9(11):2397. doi: 10.3390/microorganisms9112397.
Hydroxycarboxylic acid receptor 3 (HCA) was recently identified in the genomes of humans and other hominids but not in other mammals. We examined the production of HCA ligands by spp. In addition to 4-hydroxyphenyllactic acid, phenyllactic acid (PLA), and indole-3-lactic acid (ILA), we found that LeuA was produced by as an HCA ligand. The four ligands produced were the mixtures of enantiomers, and D-ILA, D-PLA, and D-LeuA showed stronger activity of the HCA ligand than their respective L-isomers. However, there was no difference in AhR activity between the two ILA enantiomers. These results provide new insights into the HCA ligands produced by and suggest the importance of investigating the absolute stereo structures of these metabolites.
羟基羧酸受体3（HCA）最近在人类和其他灵长类动物的基因组中被发现，但在其他哺乳动物中未被发现。我们检测了 物种产生的HCA配体。除了4-羟基苯乳酸、苯乳酸（PLA）和吲哚-3-乳酸（ILA）外，我们发现亮氨酰A（LeuA）作为一种HCA配体由 产生。产生的四种配体是对映体的混合物，并且D-ILA、D-PLA和D-LeuA作为HCA配体表现出比它们各自的L-异构体更强的活性。然而，两种ILA对映体之间的芳烃受体（AhR）活性没有差异。这些结果为 产生的HCA配体提供了新的见解，并表明研究这些代谢物的绝对立体结构的重要性。
