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用于病毒快速检测与分析的基于石墨烯的场效应晶体管生物传感器:以新冠疫情为视角

Graphene-based field-effect transistor biosensors for the rapid detection and analysis of viruses: A perspective in view of COVID-19.

作者信息

Sengupta Joydip, Hussain Chaudhery Mustansar

机构信息

Department of Electronic Science, Jogesh Chandra Chaudhuri College (Affiliated to University of Calcutta), Kolkata 700 033, W.B., India.

Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, New Jersey, USA.

出版信息

Carbon Trends. 2021 Jan;2:100011. doi: 10.1016/j.cartre.2020.100011. Epub 2020 Dec 8.

Abstract

Current situation of COVID-19 demands a rapid, reliable, cost-effective, facile detection strategy to break the transmission chain and biosensor has emerged as a feasible solution for this purpose. Introduction of nanomaterials has undoubtedly improved the performance of biosensor and the addition of graphene enhanced the sensing ability to a peerless level. Amongst different graphene-based biosensing schemes, graphene field-effect transistor marked its unique presence owing to its ability of ultrasensitive and low-noise detection thereby facilitating instantaneous measurements even in the presence of small amounts of analytes. Recently, graphene field-effect transistor type biosensor is even successfully employed in rapid detection of SARS-CoV-2 and this triggers the interest of the scientific community in reviewing the current developments in graphene field-effect transistor. Subsequently, in this article, the recent progress in graphene field-effect transistor type biosensors for the detection of the virus is reviewed and challenges along with their strengths are discussed.

摘要

新冠疫情的现状需要一种快速、可靠、经济高效且简便的检测策略来打破传播链,而生物传感器已成为实现这一目标的可行解决方案。纳米材料的引入无疑提高了生物传感器的性能,石墨烯的加入更是将传感能力提升到了无与伦比的水平。在不同的基于石墨烯的生物传感方案中,石墨烯场效应晶体管因其具有超灵敏和低噪声检测能力而脱颖而出,即使在存在少量分析物的情况下也能实现即时测量。最近,石墨烯场效应晶体管型生物传感器甚至成功应用于新冠病毒的快速检测,这引发了科学界对回顾石墨烯场效应晶体管当前发展情况的兴趣。随后,在本文中,我们将对用于检测该病毒的石墨烯场效应晶体管型生物传感器的最新进展进行综述,并讨论其面临的挑战和优势。

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