Heart, Mind & Body Research Group, Griffith University, Gold Coast, QLD 4222, Australia.
Nutrients. 2021 Oct 21;13(11):3702. doi: 10.3390/nu13113702.
As the very low-calorie ketogenic diet (VLCKD) gains increased interest as a therapeutic approach for many diseases, little is known about its therapeutic use in childhood obesity. Indeed, the role of VLCKD during pregnancy and lactation in influencing short chain fatty acid (SCFA)-producing bacteria and the potential mechanisms involved in the protective effects on obesity are still unclear. Infants are characterized by a diverse gut microbiota composition with higher abundance of SCFA-producing bacteria. Maternal VLCKD during pregnancy and lactation stimulates the growth of diverse species of SCFA-producing bacteria, which may induce epigenetic changes in infant obese gene expression and modulate adipose tissue inflammation in obesity. Therefore, this review aims to determine the mechanistic role of SCFAs in mediating VLCKD-infant gut microbiota relationships and its protective effects on obesity.
随着极低卡路里生酮饮食（VLCKD）作为治疗许多疾病的一种方法越来越受到关注，但其在儿童肥胖症中的治疗应用知之甚少。实际上，VLCKD 在怀孕期间和哺乳期对短链脂肪酸（SCFA）产生菌的影响及其对肥胖的保护作用的潜在机制仍不清楚。婴儿的肠道微生物群组成具有多样性，SCFA 产生菌的丰度较高。母亲在怀孕期间和哺乳期进行 VLCKD 会刺激多种 SCFA 产生菌的生长，这可能会导致婴儿肥胖基因表达的表观遗传变化，并调节肥胖症中的脂肪组织炎症。因此，本综述旨在确定 SCFAs 在介导 VLCKD-婴儿肠道微生物群关系及其对肥胖的保护作用中的机制作用。
