短链脂肪酸在极低卡路里生酮饮食与婴儿肠道微生物群相互作用中的作用及其在减少哮喘方面的治疗意义。
The Role of Short-Chain Fatty Acids in the Interplay between a Very Low-Calorie Ketogenic Diet and the Infant Gut Microbiota and Its Therapeutic Implications for Reducing Asthma.
机构信息
Heart, Mind & Body Research Group, Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Australia.
出版信息
Int J Mol Sci. 2020 Dec 16;21(24):9580. doi: 10.3390/ijms21249580.
Abstract
Gut microbiota is well known as playing a critical role in inflammation and asthma development. The very low-calorie ketogenic diet (VLCKD) is suggested to affect gut microbiota; however, the effects of VLCKD during pregnancy and lactation on the infant gut microbiota are unclear. The VLCKD appears to be more effective than caloric/energy restriction diets for the treatment of several diseases, such as obesity and diabetes. However, whether adherence to VLCKD affects the infant gut microbiota and the protective effects thereof on asthma remains uncertain. The exact mechanisms underlying this process, and in particular the potential role of short chain fatty acids (SCFAs), are still to be unravelled. Thus, the aim of this review is to identify the potential role of SCFAs that underlie the effects of VLCKD during pregnancy and lactation on the infant gut microbiota, and explore whether it incurs significant implications for reducing asthma.
摘要
肠道微生物群被认为在炎症和哮喘发展中起着关键作用。极低卡路里生酮饮食（VLCKD）被认为会影响肠道微生物群；然而，VLCKD 在妊娠和哺乳期对婴儿肠道微生物群的影响尚不清楚。VLCKD 似乎比热量/能量限制饮食更能有效治疗多种疾病，如肥胖症和糖尿病。然而，VLCKD 的坚持是否会影响婴儿的肠道微生物群及其对哮喘的保护作用尚不确定。这一过程的确切机制，特别是短链脂肪酸（SCFAs）的潜在作用，仍有待阐明。因此，本综述的目的是确定 VLCKD 在妊娠和哺乳期对婴儿肠道微生物群的影响所依据的 SCFAs 的潜在作用，并探讨其是否会对减少哮喘产生重大影响。
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