Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain.
Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
Nutrients. 2021 Nov 7;13(11):3968. doi: 10.3390/nu13113968.
In recent years, food ingredients rich in bioactive compounds have emerged as candidates to prevent excess adiposity and other metabolic complications characteristic of obesity, such as low-grade inflammation and oxidative status. Among them, fungi have gained popularity for their high polysaccharide content and other bioactive components with beneficial activities. Here, we use the model to investigate the potential activities of a extract (GE), together with the underlying mechanisms of action. Our study revealed that GE represents an important source of polysaccharides and phenolic compounds with in vitro antioxidant activity. Treatment with our GE extract, which was found to be nongenotoxic through a test, significantly reduced the fat content of , decreased the production of intracellular ROS and aging-lipofuscin pigment, and increased the lifespan of nematodes. Gene expression and mutant analyses demonstrated that the in vivo anti-obesity and antioxidant activities of GE were mediated through the and signalling pathways, respectively. Taken together, our results suggest that our GE extract could be considered a potential functional ingredient for the prevention of obesity-related disturbances.
近年来，富含生物活性化合物的食品成分已成为预防肥胖特征性的过度肥胖和其他代谢并发症（如低度炎症和氧化状态）的候选物。在这些成分中，真菌因其高多糖含量和其他具有有益活性的生物活性成分而受到关注。在这里，我们使用 模型来研究一种 提取物（GE）的潜在活性，以及其作用机制。我们的研究表明，GE 是一种具有体外抗氧化活性的多糖和酚类化合物的重要来源。通过 试验发现，我们的 GE 提取物无遗传毒性，用其处理可显著降低 的脂肪含量，减少细胞内 ROS 和衰老脂褐素色素的产生，并延长线虫的寿命。基因表达和突变分析表明，GE 的体内抗肥胖和抗氧化活性分别通过 和 信号通路介导。总之，我们的研究结果表明，我们的 GE 提取物可被视为预防肥胖相关紊乱的潜在功能性成分。
